RUNX1-3

Information RUNX1-3

Description

Targets RUNX1 and 3. Runt-related transcription factor 1: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (Source UniProtKB).

Full Name

Targets RUNX1 and 3

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
1,179
Non-redundant peaks
1,179

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

JASPAR
Ensembl
UniProt
Q01196
Genevisible
Q01196
RefSeq
Aliases
AML1; AML2; CBFA2; CBFA3; PEBP2A3
All peaks RUNX1-3
Download BED file
Non redundant peaks RUNX1-3
Download BED file
SEQUENCES RUNX1-3
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for RUNX1-3

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RUNX1-3 Jurkat GEO Homo sapiens GSE17954 1,179
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks