RUNX1-RUNX1T1
Information RUNX1-RUNX1T1
- Description
Fusion of RUNX1 and RUNX1T1. Runt-related transcription factor 1: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (Source UniProtKB).
- Full Name
Fusion of RUNX1 and RUNX1T1
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 16,701
- Non-redundant peaks
- 16,437
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
Datasets Table for RUNX1-RUNX1T1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| RUNX1-RUNX1T1 | AML | GEO | Homo sapiens | GSE131939 | 16,398 | |||
| RUNX1-RUNX1T1 | AML | shaml1-eto | GEO | Homo sapiens | GSE131939 | 303 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |