RUNX1

Information RUNX1

Description

Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (PubMed:23481257). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (PubMed:21151104). {ECO:0000250|UniProtKB:Q01196, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18258917, ECO:0000269|PubMed:21151104, ECO:0000269|PubMed:23481257, ECO:0000305}.; Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000269|PubMed:11203699}.

Full Name

runt related transcription factor 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
43
Biotypes
23
Peaks
1,054,288
Non-redundant peaks
345,054

TF Classification

Familly
Runt domain factors
Sub Familly
Runt-related factors

Source JASPAR

External IDs

NCBI Gene
12394
Official Gene Name
Runx1
JASPAR
MA0002.2
MGI
MGI:99852
Ensembl
ENSMUSG00000022952
UniProt
Q03347
Genevisible
Q03347
RefSeq
NM_009821
Aliases
AML1; CBF-alpha-2; Cbfa2; Pebp2a2; Pebpa2b; runt domain, alpha subunit 2
All peaks RUNX1
Download BED file
Non redundant peaks RUNX1
Download BED file
SEQUENCES RUNX1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for RUNX1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RUNX1 EML GEO Mus musculus GSE75186 31,508
RUNX1 T-cell mock GEO Mus musculus GSE93755 43,706
RUNX1 T-cell GEO Mus musculus GSE93755 52,172
RUNX1 CD4-pos Naive GEO Mus musculus GSE67443 11,227
RUNX1 CD4-pos PMA GEO Mus musculus GSE67443 36,949
RUNX1 liver GEO Mus musculus GSE42108 457
RUNX1 416B CBFB-MYH11_Dox GEO Mus musculus GSE83956 17,619
RUNX1 416B CBFB-MYH11 GEO Mus musculus GSE83956 28,984
RUNX1 MEF GEO Mus musculus GSE90893 55,559
RUNX1 thymocyte GEO Mus musculus GSE33653 2,080
RUNX1 pre-B-cell GEO Mus musculus GSE126375 36,381
RUNX1 BMDC 2h GEO Mus musculus GSE36099 428
RUNX1 BMDC GEO Mus musculus GSE36099 1,568
RUNX1 BMDC 1h GEO Mus musculus GSE36099 3,024
RUNX1 hematopoietic-progenitor GEO Mus musculus GSE84328 22,929
RUNX1 thymus GEO Mus musculus GSE98662 53,208
RUNX1 myeloid-progenitor-expansion uninduced GEO Mus musculus GSE64589 20,287
RUNX1 pro-T-cell GEO Mus musculus GSE131082 41,796
RUNX1 megakaryocyte GEO Mus musculus GSE45372 1,662
RUNX1 pro-B-cell GEO Mus musculus GSE126375 33,179
RUNX1 pro-B-cell GEO Mus musculus GSE45377 7,788
RUNX1 lung GEO Mus musculus GSE111871 2,720
RUNX1 bone-marrow vitc GEO Mus musculus GSE87623 10,422
RUNX1 bone-marrow unt GEO Mus musculus GSE87623 8,458
RUNX1 ovary E14-5 GEO Mus musculus GSE128767 20,385
RUNX1 BMDM B6 GEO Mus musculus GSE109965 43,364
RUNX1 L8057 uninduced GEO Mus musculus GSE33653 63,402
RUNX1 L8057 Rnf2-alt-AB GEO Mus musculus GSE33653 14,162
RUNX1 hemogenic-endothelium GEO Mus musculus GSE104045 3,188
RUNX1 hemogenic-endothelium Dox-JQ1 GEO Mus musculus GSE104045 63,416
RUNX1 myeloid-progenitor-expansion induced GEO Mus musculus GSE64589 14,764
RUNX1 EML GEO Mus musculus GSE31221 18,862
RUNX1 EML GEO Mus musculus GSE62596 14,291
RUNX1 CD4-pos GEO Mus musculus GSE67443 475
RUNX1 ILC2 GEO Mus musculus GSE131082 66,229
RUNX1 BMDM KLA_B6 GEO Mus musculus GSE109965 55,400
RUNX1 MEF 48h GEO Mus musculus GSE90893 41,470
RUNX1 pro-B-cell Ebf1-KO GEO Mus musculus GSE126375 53,721
RUNX1 pro-B-cell Pax5-KO GEO Mus musculus GSE126375 53,626
RUNX1 L8057 induced GEO Mus musculus GSE33653 8,061
RUNX1 HPC-7 GEO Mus musculus GSE22178 6,391
RUNX1 416B Dox GEO Mus musculus GSE83956 23,973
RUNX1 416B GEO Mus musculus GSE83956 24,638
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks