RUNX1
Information RUNX1
- Description
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917). CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (PubMed:23481257). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (PubMed:21151104). {ECO:0000250|UniProtKB:Q01196, ECO:0000269|PubMed:17377532, ECO:0000269|PubMed:18258917, ECO:0000269|PubMed:21151104, ECO:0000269|PubMed:23481257, ECO:0000305}.; Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. {ECO:0000269|PubMed:11203699}.
- Full Name
runt related transcription factor 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 43
- Biotypes
- 23
- Peaks
- 1,054,288
- Non-redundant peaks
- 345,054
TF Classification
- Familly
- Runt domain factors
- Sub Familly
- Runt-related factors
Source JASPAR
Datasets Table for RUNX1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
RUNX1 | EML | GEO | Mus musculus | GSE75186 | 31,508 | |||
RUNX1 | T-cell | mock | GEO | Mus musculus | GSE93755 | 43,706 | ||
RUNX1 | T-cell | GEO | Mus musculus | GSE93755 | 52,172 | |||
RUNX1 | CD4-pos | Naive | GEO | Mus musculus | GSE67443 | 11,227 | ||
RUNX1 | CD4-pos | PMA | GEO | Mus musculus | GSE67443 | 36,949 | ||
RUNX1 | liver | GEO | Mus musculus | GSE42108 | 457 | |||
RUNX1 | 416B | CBFB-MYH11_Dox | GEO | Mus musculus | GSE83956 | 17,619 | ||
RUNX1 | 416B | CBFB-MYH11 | GEO | Mus musculus | GSE83956 | 28,984 | ||
RUNX1 | MEF | GEO | Mus musculus | GSE90893 | 55,559 | |||
RUNX1 | thymocyte | GEO | Mus musculus | GSE33653 | 2,080 | |||
RUNX1 | pre-B-cell | GEO | Mus musculus | GSE126375 | 36,381 | |||
RUNX1 | BMDC | 2h | GEO | Mus musculus | GSE36099 | 428 | ||
RUNX1 | BMDC | GEO | Mus musculus | GSE36099 | 1,568 | |||
RUNX1 | BMDC | 1h | GEO | Mus musculus | GSE36099 | 3,024 | ||
RUNX1 | hematopoietic-progenitor | GEO | Mus musculus | GSE84328 | 22,929 | |||
RUNX1 | thymus | GEO | Mus musculus | GSE98662 | 53,208 | |||
RUNX1 | myeloid-progenitor-expansion | uninduced | GEO | Mus musculus | GSE64589 | 20,287 | ||
RUNX1 | pro-T-cell | GEO | Mus musculus | GSE131082 | 41,796 | |||
RUNX1 | megakaryocyte | GEO | Mus musculus | GSE45372 | 1,662 | |||
RUNX1 | pro-B-cell | GEO | Mus musculus | GSE126375 | 33,179 | |||
RUNX1 | pro-B-cell | GEO | Mus musculus | GSE45377 | 7,788 | |||
RUNX1 | lung | GEO | Mus musculus | GSE111871 | 2,720 | |||
RUNX1 | bone-marrow | vitc | GEO | Mus musculus | GSE87623 | 10,422 | ||
RUNX1 | bone-marrow | unt | GEO | Mus musculus | GSE87623 | 8,458 | ||
RUNX1 | ovary | E14-5 | GEO | Mus musculus | GSE128767 | 20,385 | ||
RUNX1 | BMDM | B6 | GEO | Mus musculus | GSE109965 | 43,364 | ||
RUNX1 | L8057 | uninduced | GEO | Mus musculus | GSE33653 | 63,402 | ||
RUNX1 | L8057 | Rnf2-alt-AB | GEO | Mus musculus | GSE33653 | 14,162 | ||
RUNX1 | hemogenic-endothelium | GEO | Mus musculus | GSE104045 | 3,188 | |||
RUNX1 | hemogenic-endothelium | Dox-JQ1 | GEO | Mus musculus | GSE104045 | 63,416 | ||
RUNX1 | myeloid-progenitor-expansion | induced | GEO | Mus musculus | GSE64589 | 14,764 | ||
RUNX1 | EML | GEO | Mus musculus | GSE31221 | 18,862 | |||
RUNX1 | EML | GEO | Mus musculus | GSE62596 | 14,291 | |||
RUNX1 | CD4-pos | GEO | Mus musculus | GSE67443 | 475 | |||
RUNX1 | ILC2 | GEO | Mus musculus | GSE131082 | 66,229 | |||
RUNX1 | BMDM | KLA_B6 | GEO | Mus musculus | GSE109965 | 55,400 | ||
RUNX1 | MEF | 48h | GEO | Mus musculus | GSE90893 | 41,470 | ||
RUNX1 | pro-B-cell | Ebf1-KO | GEO | Mus musculus | GSE126375 | 53,721 | ||
RUNX1 | pro-B-cell | Pax5-KO | GEO | Mus musculus | GSE126375 | 53,626 | ||
RUNX1 | L8057 | induced | GEO | Mus musculus | GSE33653 | 8,061 | ||
RUNX1 | HPC-7 | GEO | Mus musculus | GSE22178 | 6,391 | |||
RUNX1 | 416B | Dox | GEO | Mus musculus | GSE83956 | 23,973 | ||
RUNX1 | 416B | GEO | Mus musculus | GSE83956 | 24,638 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |