RXR

Antibody targetting all RXR-alpha etc… Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA. (Source UniProtKB).

Targets all RXR(A,B,..)

Source NCBI

Homo sapiens [tax_id: 9606]

hg38