RXRA-B

Information RXRA-B

Description

Targets RXRA and RXRB. Retinoic acid receptor RXR-alpha/beta. Receptor for retinoic acid that acts as a transcription factor (PubMed:10383391, PubMed:12032153, PubMed:25417649). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:1310259, PubMed:10383391). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:1310259). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:10383391, PubMed:25417649). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (By similarity). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:1310259). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (By similarity). (Source UniProtKB)

Full Name

RXRA-B

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
4
Biotypes
1
Peaks
245,931
Non-redundant peaks
129,283

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

JASPAR
MGI
Ensembl
UniProt
P28700
Genevisible
P28700
RefSeq
Aliases
All peaks RXRA-B
Download BED file
Non redundant peaks RXRA-B
Download BED file
SEQUENCES RXRA-B
Download FASTA file
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Datasets Table for RXRA-B

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RXRA-B liver ZT14 GEO Mus musculus GSE135423 75,053
RXRA-B liver ZT02 GEO Mus musculus GSE135423 34,350
RXRA-B liver ZT06 GEO Mus musculus GSE135423 64,055
RXRA-B liver ZT26 GEO Mus musculus GSE135423 72,473
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks