SATB1

Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (PubMed:26305964). {ECO:0000250, ECO:0000269|PubMed:10716941, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:15814699, ECO:0000269|PubMed:17057718, ECO:0000269|PubMed:18722016, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19386260, ECO:0000269|PubMed:26305964, ECO:0000269|PubMed:9271405}.(Source UnitProtKB).

special AT-rich sequence binding protein 1

Source UniprotKB

Mus musculus [tax_id: 10090]

mm10