SETDB1

Information SETDB1

Description

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (PubMed:11791185, PubMed:22939622). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (By similarity). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (By similarity). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (PubMed:20164836, PubMed:29728365). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity). {ECO:0000250|UniProtKB:Q15047, ECO:0000269|PubMed:11791185, ECO:0000269|PubMed:20164836, ECO:0000269|PubMed:22939622, ECO:0000269|PubMed:29728365}.

Full Name

SET domain, bifurcated 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
14
Biotypes
8
Peaks
55,718
Non-redundant peaks
48,430

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
84505
Official Gene Name
Setdb1
JASPAR
MGI
MGI:1934229
Ensembl
ENSMUSG00000015697
UniProt
O88974
Genevisible
O88974
RefSeq
NM_018877
Aliases
ESET; KMT1E
All peaks SETDB1
Download BED file
Non redundant peaks SETDB1
Download BED file
SEQUENCES SETDB1
Download FASTA file
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Datasets Table for SETDB1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SETDB1 liver old GEO Mus musculus GSE130712 132
SETDB1 C2C12 GEO Mus musculus GSE65493 521
SETDB1 MSC GEO Mus musculus GSE73432 1,796
SETDB1 mESC GEO Mus musculus GSE73432 611
SETDB1 pro-B-cell sc GEO Mus musculus GSE77636 1,802
SETDB1 3T3-L1 siCtr GEO Mus musculus GSE73432 5,079
SETDB1 3T3-L1 siMcaf1 GEO Mus musculus GSE73432 2,139
SETDB1 3T3-L1 D6 GEO Mus musculus GSE73432 920
SETDB1 3T3-L1 D0 GEO Mus musculus GSE73432 366
SETDB1 mESC-E14 GEO Mus musculus GSE17642 7,326
SETDB1 liver-hepatoma GEO Mus musculus GSE87734 1,150
SETDB1 liver young GEO Mus musculus GSE130712 112
SETDB1 pro-B-cell GEO Mus musculus GSE77636 29,999
SETDB1 3T3-L1 SiMbd1 GEO Mus musculus GSE73432 3,765
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks