SIN3A
Information SIN3A
- Description
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904). Required for cortical neuron differentiation and callosal axon elongation (PubMed:27399968). {ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:21680841, ECO:0000269|PubMed:22476904, ECO:0000269|PubMed:27399968, ECO:0000269|PubMed:7889570, ECO:0000269|PubMed:8649810}.(Source UnitProtKB).
- Full Name
transcriptional regulator, SIN3A (yeast)
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 15
- Biotypes
- 6
- Peaks
- 230,242
- Non-redundant peaks
- 94,013
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 20466
- Official Gene Name
- Sin3a
- JASPAR
- MGI
- MGI:107157
- Ensembl
- ENSMUSG00000042557
- UniProt
- Q60520
- Genevisible
- Q60520
- RefSeq
- Aliases
- AW553200; Sin3; mKIAA4126; mSin3A
Datasets Table for SIN3A
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SIN3A | MEL | ENCODE | Mus musculus | ENCSR000ETC | 35,131 | |||
| SIN3A | MEF | D3 | GEO | Mus musculus | GSE98404 | 5,648 | ||
| SIN3A | C2C12 | MT | GEO | Mus musculus | GSE50590 | 8,584 | ||
| SIN3A | C2C12 | myotube | GEO | Mus musculus | GSE22554 | 1,626 | ||
| SIN3A | mESC | ZFP296-KO_C7 | GEO | Mus musculus | GSE117287 | 8,356 | ||
| SIN3A | mESC | GEO | Mus musculus | GSE117287 | 43,134 | |||
| SIN3A | mESC | Abcam | GEO | Mus musculus | GSE24841 | 19,887 | ||
| SIN3A | mESC | GEO | Mus musculus | GSE81081 | 11,995 | |||
| SIN3A | NSC | pre-iPSCs | GEO | Mus musculus | GSE91021 | 5,058 | ||
| SIN3A | NSC | pre-iPSCs_Nanog-FLAG-SIN3A | GEO | Mus musculus | GSE91021 | 4,568 | ||
| SIN3A | CH12-LX | ENCODE | Mus musculus | ENCSR000EQY | 14,959 | |||
| SIN3A | mESC | SCruz | GEO | Mus musculus | GSE24841 | 15,686 | ||
| SIN3A | mESC | ZFP296-KO_C27 | GEO | Mus musculus | GSE117287 | 31,440 | ||
| SIN3A | mESC | spikein | GEO | Mus musculus | GSE117287 | 15,494 | ||
| SIN3A | C2C12 | GEO | Mus musculus | GSE56932 | 8,676 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |