SIX2

Information SIX2

Description

Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation (PubMed:20515681). During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1 (PubMed:19660448). During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway (PubMed:18321982). Also may be involved in limb tendon and ligament development (PubMed:7720577). Plays a role in cell proliferation and migration (By similarity). {ECO:0000250|UniProtKB:Q9NPC8, ECO:0000269|PubMed:17036046, ECO:0000269|PubMed:18321982, ECO:0000269|PubMed:18682239, ECO:0000269|PubMed:19660448, ECO:0000269|PubMed:20515681, ECO:0000269|PubMed:21350016, ECO:0000269|PubMed:22902740, ECO:0000269|PubMed:24598167, ECO:0000269|PubMed:7720577}.(Source UnitProtKB).

Full Name

sine oculis-related homeobox 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
5
Biotypes
3
Peaks
200,842
Non-redundant peaks
104,517

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
20472
Official Gene Name
Six2
JASPAR
MGI
MGI:102778
Ensembl
ENSMUSG00000024134
UniProt
Q62232
Genevisible
Q62232
RefSeq
NM_011380
Aliases
All peaks SIX2
Download BED file
Non redundant peaks SIX2
Download BED file
SEQUENCES SIX2
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for SIX2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SIX2 embryonic-kidney GEO Mus musculus GSE73865 78,811
SIX2 embryonic-kidney hu GEO Mus musculus GSE73865 49,578
SIX2 kidney E16-5_B6 GEO Mus musculus GSE90016 12,044
SIX2 nephron-progenitor GEO Mus musculus GSE39837 45,554
SIX2 kidney E16-5_SJL GEO Mus musculus GSE90016 14,855
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks