SMAD2-3
Information SMAD2-3
- Description
Targeting both SMAD2 and SMAD3. Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). (Source UniProtKB)
- Full Name
SMAD2-3
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 19
- Biotypes
- 6
- Peaks
- 383,414
- Non-redundant peaks
- 149,804
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
Datasets Table for SMAD2-3
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SMAD2-3 | pancreas | RREB1_KO | GEO | Mus musculus | GSE118765 | 10,890 | ||
| SMAD2-3 | pancreas-cancer | TGFb | GEO | Mus musculus | GSE72069 | 13,565 | ||
| SMAD2-3 | pancreas-cancer | GEO | Mus musculus | GSE72069 | 28,564 | |||
| SMAD2-3 | mESC | GEO | Mus musculus | GSE70486 | 755 | |||
| SMAD2-3 | mESC | activin | GEO | Mus musculus | GSE21614 | 1,254 | ||
| SMAD2-3 | mESC | GEO | Mus musculus | GSE53233 | 39,399 | |||
| SMAD2-3 | NmuMG | GEO | Mus musculus | GSE121254 | 11,972 | |||
| SMAD2-3 | SCC | GEO | Mus musculus | GSE74762 | 30,646 | |||
| SMAD2-3 | pancreas | RREB1_TGFb | GEO | Mus musculus | GSE118765 | 60,185 | ||
| SMAD2-3 | EBs | GEO | Mus musculus | GSE118765 | 27,474 | |||
| SMAD2-3 | EBs | activin_Trp53-KO | GEO | Mus musculus | GSE70486 | 25,607 | ||
| SMAD2-3 | pancreas | TGFb | GEO | Mus musculus | GSE118765 | 27,531 | ||
| SMAD2-3 | EBs | GEO | Mus musculus | GSE70486 | 362 | |||
| SMAD2-3 | pancreas | RREB1_TGFb_KO | GEO | Mus musculus | GSE118765 | 37,029 | ||
| SMAD2-3 | pancreas | RREB1 | GEO | Mus musculus | GSE118765 | 1,055 | ||
| SMAD2-3 | EBs | activin_BL6J | GEO | Mus musculus | GSE70486 | 22,850 | ||
| SMAD2-3 | EBs | Trp53-KO | GEO | Mus musculus | GSE70486 | 15,358 | ||
| SMAD2-3 | EBs | Activin | GEO | Mus musculus | GSE70486 | 14,095 | ||
| SMAD2-3 | EBs | BL6J | GEO | Mus musculus | GSE70486 | 14,823 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |