SMAD2-3

Description: Targets SMAD2 and 3. Mothers against decapentaplegic homolog 2 : Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. (Source UniProtKB).
Full Name: Targets SMAD2 and 3; Source NCBI
Species: Homo sapiens [tax_id: 9606]
Genome: hg38

All peaks SMAD2-3

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Non redundant peaks SMAD2-3

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SEQUENCES SMAD2-3

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Target name	Target modification	Ecotype/Strain	Biotype	Biotype modification	Source	Species	Experiment	Peaks
SMAD2-3			HGrC1	C134W-TGF_parental	GEO	Homo sapiens	GSE138496	601
SMAD2-3			HGrC1	C134W	GEO	Homo sapiens	GSE138496	5,226
SMAD2-3			HGrC1	EV-TGF	GEO	Homo sapiens	GSE138496	17,105
SMAD2-3			HGrC1	WT	GEO	Homo sapiens	GSE138496	24,747
SMAD2-3			HGrC1	C134W-TGF	GEO	Homo sapiens	GSE138496	40,714
SMAD2-3			HGrC1	EV	GEO	Homo sapiens	GSE138496	28,238
SMAD2-3			HGrC1	WT-TGF	GEO	Homo sapiens	GSE138496	20,384
SMAD2-3			HGrC1	C134W-TGF_SMAD4-KO	GEO	Homo sapiens	GSE138496	5,587
SMAD2-3			HUVEC-C	TGFB1	GEO	Homo sapiens	GSE134556	65,050
SMAD2-3			aortic-smooth-muscle-cell	TGFB1	GEO	Homo sapiens	GSE134556	1,074
Target name	Target modification	Ecotype/Strain	Biotype	Biotype modification	Source	Species	Experiment	Peaks

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