SMAD2
Information SMAD2
- Description
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250|UniProtKB:Q15796, ECO:0000269|PubMed:15356634}.(Source UnitProtKB).
- Full Name
SMAD family member 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 9
- Biotypes
- 3
- Peaks
- 97,071
- Non-redundant peaks
- 55,943
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 17126
- Official Gene Name
- Smad2
- JASPAR
- MGI
- MGI:108051
- Ensembl
- ENSMUSG00000024563
- UniProt
- Q62432
- Genevisible
- Q62432
- RefSeq
- NM_010754
- Aliases
- 7120426M23Rik; Madh2; Madr2; Smad 2; Smad-2; mMad2
Datasets Table for SMAD2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SMAD2 | P19 | Activin-8h | GEO | Mus musculus | GSE77454 | 5,181 | ||
| SMAD2 | P19 | GEO | Mus musculus | GSE77454 | 2,119 | |||
| SMAD2 | mESC | GEO | Mus musculus | GSE125116 | 22,515 | |||
| SMAD2 | mESC | DMSO | GEO | Mus musculus | GSE23581 | 1,465 | ||
| SMAD2 | mESC | SB | GEO | Mus musculus | GSE23581 | 1,244 | ||
| SMAD2 | EBs | SB431542 | GEO | Mus musculus | GSE125116 | 29,785 | ||
| SMAD2 | mESC | activin | GEO | Mus musculus | GSE23581 | 758 | ||
| SMAD2 | EBs | Activin | GEO | Mus musculus | GSE125116 | 33,092 | ||
| SMAD2 | P19 | Activin-1h | GEO | Mus musculus | GSE77454 | 912 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |