SMAD3-EPAS1

Information SMAD3-EPAS1

Description

Fusion of SMAD3 and EPAS1. Mothers against decapentaplegic homolog 3: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. (Source UniProtKB). Hypoxia-inducible factor 1-alpha : Functions as a master transcriptional regulator of the adaptive response to hypoxia. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. (Source UniProtKB)

Full Name

Fusion of SMAD3 and EPAS1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
5,448
Non-redundant peaks
5,448

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

JASPAR
Ensembl
UniProt
P84022
Genevisible
P84022
RefSeq
Aliases
BHLHE73; EPAS1; HIF2A; MADH3; MOP2; PASD2; SMAD3
All peaks SMAD3-EPAS1
Download BED file
Non redundant peaks SMAD3-EPAS1
Download BED file
SEQUENCES SMAD3-EPAS1
Download FASTA file
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Datasets Table for SMAD3-EPAS1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SMAD3-EPAS1 PC-3 hypoxia GEO Homo sapiens GSE106305 5,448
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks