SMAD3

Information SMAD3

Description

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250|UniProtKB:P84022, ECO:0000269|PubMed:10559937, ECO:0000269|PubMed:11585338, ECO:0000269|PubMed:14617288, ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:21035443}.(Source UnitProtKB).

Full Name

SMAD family member 3

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
20
Biotypes
8
Peaks
457,595
Non-redundant peaks
210,570

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
17127
Official Gene Name
Smad3
JASPAR
MGI
MGI:1201674
Ensembl
ENSMUSG00000032402
UniProt
Q8BUN5
Genevisible
Q8BUN5
RefSeq
NM_016769
Aliases
AU022421; Madh3; Smad 3
All peaks SMAD3
Download BED file
Non redundant peaks SMAD3
Download BED file
SEQUENCES SMAD3
Download FASTA file
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Datasets Table for SMAD3

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SMAD3 MEF GEO Mus musculus GSE85177 11,312
SMAD3 MEF Dox GEO Mus musculus GSE85177 12,416
SMAD3 VSMC shNT GEO Mus musculus GSE112417 60,736
SMAD3 mESC activin GEO Mus musculus GSE21614 3,651
SMAD3 mESC Myod1-d2 GEO Mus musculus GSE21614 17,387
SMAD3 mESC Myod1-d5 GEO Mus musculus GSE21614 28,132
SMAD3 mESC d2_Myod1 GEO Mus musculus GSE21614 17,387
SMAD3 mESC d5 GEO Mus musculus GSE21614 4,458
SMAD3 mESC d2 GEO Mus musculus GSE21614 6,101
SMAD3 mESC GEO Mus musculus GSE125116 31,461
SMAD3 mESC d5_Myod1 GEO Mus musculus GSE21614 28,132
SMAD3 pro-B-cell GEO Mus musculus GSE21614 104
SMAD3 EBs SB431542 GEO Mus musculus GSE125116 62,530
SMAD3 myotube GEO Mus musculus GSE21614 129
SMAD3 NSC GEO Mus musculus GSE36673 40,427
SMAD3 BMDM veh-6h GEO Mus musculus GSE72964 2,037
SMAD3 BMDM GEO Mus musculus GSE72964 32,504
SMAD3 BMDM TGFb-4h GEO Mus musculus GSE72964 31,878
SMAD3 BMDM homog-6h GEO Mus musculus GSE72964 15,727
SMAD3 EBs Activin GEO Mus musculus GSE125116 51,086
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks