SMAD3
Information SMAD3
- Description
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250|UniProtKB:P84022, ECO:0000269|PubMed:10559937, ECO:0000269|PubMed:11585338, ECO:0000269|PubMed:14617288, ECO:0000269|PubMed:15356634, ECO:0000269|PubMed:21035443}.(Source UnitProtKB).
- Full Name
SMAD family member 3
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 20
- Biotypes
- 8
- Peaks
- 457,595
- Non-redundant peaks
- 210,570
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 17127
- Official Gene Name
- Smad3
- JASPAR
- MGI
- MGI:1201674
- Ensembl
- ENSMUSG00000032402
- UniProt
- Q8BUN5
- Genevisible
- Q8BUN5
- RefSeq
- NM_016769
- Aliases
- AU022421; Madh3; Smad 3
Datasets Table for SMAD3
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
SMAD3 | MEF | GEO | Mus musculus | GSE85177 | 11,312 | |||
SMAD3 | MEF | Dox | GEO | Mus musculus | GSE85177 | 12,416 | ||
SMAD3 | VSMC | shNT | GEO | Mus musculus | GSE112417 | 60,736 | ||
SMAD3 | mESC | activin | GEO | Mus musculus | GSE21614 | 3,651 | ||
SMAD3 | mESC | Myod1-d2 | GEO | Mus musculus | GSE21614 | 17,387 | ||
SMAD3 | mESC | Myod1-d5 | GEO | Mus musculus | GSE21614 | 28,132 | ||
SMAD3 | mESC | d2_Myod1 | GEO | Mus musculus | GSE21614 | 17,387 | ||
SMAD3 | mESC | d5 | GEO | Mus musculus | GSE21614 | 4,458 | ||
SMAD3 | mESC | d2 | GEO | Mus musculus | GSE21614 | 6,101 | ||
SMAD3 | mESC | GEO | Mus musculus | GSE125116 | 31,461 | |||
SMAD3 | mESC | d5_Myod1 | GEO | Mus musculus | GSE21614 | 28,132 | ||
SMAD3 | pro-B-cell | GEO | Mus musculus | GSE21614 | 104 | |||
SMAD3 | EBs | SB431542 | GEO | Mus musculus | GSE125116 | 62,530 | ||
SMAD3 | myotube | GEO | Mus musculus | GSE21614 | 129 | |||
SMAD3 | NSC | GEO | Mus musculus | GSE36673 | 40,427 | |||
SMAD3 | BMDM | veh-6h | GEO | Mus musculus | GSE72964 | 2,037 | ||
SMAD3 | BMDM | GEO | Mus musculus | GSE72964 | 32,504 | |||
SMAD3 | BMDM | TGFb-4h | GEO | Mus musculus | GSE72964 | 31,878 | ||
SMAD3 | BMDM | homog-6h | GEO | Mus musculus | GSE72964 | 15,727 | ||
SMAD3 | EBs | Activin | GEO | Mus musculus | GSE125116 | 51,086 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |