SMARCC1

Information SMARCC1

Description

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250|UniProtKB:Q92922, ECO:0000269|PubMed:11604513, ECO:0000269|PubMed:17640523, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.(Source UnitProtKB).

Full Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
3
Biotypes
2
Peaks
86,078
Non-redundant peaks
80,796

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
20588
Official Gene Name
Smarcc1
JASPAR
MGI
MGI:1203524
Ensembl
ENSMUSG00000032481
UniProt
P97496
Genevisible
P97496
RefSeq
NM_009211
Aliases
AI115498; BAF155; Rsc8; SRG3; msp3
All peaks SMARCC1
Download BED file
Non redundant peaks SMARCC1
Download BED file
SEQUENCES SMARCC1
Download FASTA file
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Datasets Table for SMARCC1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SMARCC1 MEF Smarcb1 GEO Mus musculus GSE71507 7,394
SMARCC1 MEF GEO Mus musculus GSE71507 71,092
SMARCC1 mESC GEO Mus musculus GSE80049 7,592
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks