SMARCC1
Information SMARCC1
- Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250|UniProtKB:Q92922, ECO:0000269|PubMed:11604513, ECO:0000269|PubMed:17640523, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.(Source UnitProtKB).
- Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 86,078
- Non-redundant peaks
- 80,796
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 20588
- Official Gene Name
- Smarcc1
- JASPAR
- MGI
- MGI:1203524
- Ensembl
- ENSMUSG00000032481
- UniProt
- P97496
- Genevisible
- P97496
- RefSeq
- NM_009211
- Aliases
- AI115498; BAF155; Rsc8; SRG3; msp3
Datasets Table for SMARCC1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
SMARCC1 | MEF | Smarcb1 | GEO | Mus musculus | GSE71507 | 7,394 | ||
SMARCC1 | MEF | GEO | Mus musculus | GSE71507 | 71,092 | |||
SMARCC1 | mESC | GEO | Mus musculus | GSE80049 | 7,592 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |