SMC1A-B
Information SMC1A-B
- Description
Targets SMC1A and B. SMC1A: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. (Source UniProtKB)
- Full Name
Targets SMC1A and B
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 4
- Biotypes
- 3
- Peaks
- 82,700
- Non-redundant peaks
- 41,053
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
Datasets Table for SMC1A-B
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SMC1A-B | Kelly | shB4-res | GEO | Homo sapiens | GSE115248 | 7,933 | ||
| SMC1A-B | Kelly | shLUC-res | GEO | Homo sapiens | GSE115248 | 21,459 | ||
| SMC1A-B | TC-32 | GEO | Homo sapiens | GSE115250 | 33,506 | |||
| SMC1A-B | TC-71 | GEO | Homo sapiens | GSE115250 | 19,802 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |