SMC1A-B

Information SMC1A-B

Description

Targets SMC1A and B. SMC1A: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. (Source UniProtKB)

Full Name

Targets SMC1A and B

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
4
Biotypes
3
Peaks
82,700
Non-redundant peaks
41,053

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

JASPAR
Ensembl
UniProt
Q14683
Genevisible
Q14683
RefSeq
Aliases
DXS423E; KIAA0178; SB1.8; SMC1; SMC1A; SMC1B; SMC1L1; SMC1L2
All peaks SMC1A-B
Download BED file
Non redundant peaks SMC1A-B
Download BED file
SEQUENCES SMC1A-B
Download FASTA file
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Datasets Table for SMC1A-B

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SMC1A-B Kelly shB4-res GEO Homo sapiens GSE115248 7,933
SMC1A-B Kelly shLUC-res GEO Homo sapiens GSE115248 21,459
SMC1A-B TC-32 GEO Homo sapiens GSE115250 33,506
SMC1A-B TC-71 GEO Homo sapiens GSE115250 19,802
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks