SMC1A
Information SMC1A
- Description
Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000250}.(Source UnitProtKB).
- Full Name
structural maintenance of chromosomes 1A
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 48
- Biotypes
- 21
- Peaks
- 1,678,563
- Non-redundant peaks
- 397,934
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 24061
- Official Gene Name
- Smc1a
- JASPAR
- MGI
- MGI:1344345
- Ensembl
- ENSMUSG00000041133
- UniProt
- Q9CU62
- Genevisible
- Q9CU62
- RefSeq
- Aliases
- 5830426I24Rik; SB1.8; SMC-1A; SMCB; Sb1.8; Smc1; Smc1alpha; Smc1l1; Smcb; mKIAA0178
Datasets Table for SMC1A
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
SMC1A | fibroblast | Xist-del | GEO | Mus musculus | GSE67516 | 33,367 | ||
SMC1A | fibroblast | GEO | Mus musculus | GSE67516 | 35,847 | |||
SMC1A | HPC-7 | Ery_Luc | GEO | Mus musculus | GSE129478 | 19,768 | ||
SMC1A | HPC-7 | Ery_shStag2 | GEO | Mus musculus | GSE129478 | 48,496 | ||
SMC1A | HPC-7 | shRad21 | GEO | Mus musculus | GSE129478 | 24,147 | ||
SMC1A | MEF | GEO | Mus musculus | GSE32319 | 25,449 | |||
SMC1A | MEF | GEO | Mus musculus | GSE22562 | 55,749 | |||
SMC1A | MEF | Stag1-KO | GEO | Mus musculus | GSE32319 | 50,242 | ||
SMC1A | cortex | GEO | Mus musculus | GSE42237 | 1,063 | |||
SMC1A | embryonic-brain | GEO | Mus musculus | GSE117184 | 13,085 | |||
SMC1A | uterus | 4h | GEO | Mus musculus | GSE125972 | 53,558 | ||
SMC1A | mESC | Tg2a_I | GEO | Mus musculus | GSE131356 | 48,668 | ||
SMC1A | mESC | siCtrl | GEO | Mus musculus | GSE115340 | 11,427 | ||
SMC1A | mESC | serum | GEO | Mus musculus | GSE92407 | 53,993 | ||
SMC1A | mESC | GEO | Mus musculus | GSE22562 | 6,374 | |||
SMC1A | mESC | DRC | GEO | Mus musculus | GSE92745 | 11,137 | ||
SMC1A | mESC | EpiLSC | GEO | Mus musculus | GSE92407 | 53,013 | ||
SMC1A | mESC | GRHL2-HA | GEO | Mus musculus | GSE92745 | 11,850 | ||
SMC1A | mESC | 1d | GEO | Mus musculus | GSE126362 | 50,713 | ||
SMC1A | mESC | GEO | Mus musculus | GSE126362 | 54,299 | |||
SMC1A | HSPC | Stag2WT | GEO | Mus musculus | GSE138005 | 274 | ||
SMC1A | mammary-gland | WT | GEO | Mus musculus | GSE92591 | 42,269 | ||
SMC1A | limb | GEO | Mus musculus | GSE42237 | 43,212 | |||
SMC1A | distal-forelimb | GEO | Mus musculus | GSE101714 | 23,991 | |||
SMC1A | AtT-20 | GEO | Mus musculus | GSE87180 | 8,698 | |||
SMC1A | bone-marrow | KO | GEO | Mus musculus | GSE83960 | 45,977 | ||
SMC1A | TSC | CB | GEO | Mus musculus | GSE118399 | 55,760 | ||
SMC1A | epiblast-cell | KO | GEO | Mus musculus | GSE92745 | 29,004 | ||
SMC1A | epiblast-cell | DRC | GEO | Mus musculus | GSE92745 | 11,194 | ||
SMC1A | epiblast-cell | GEO | Mus musculus | GSE92745 | 31,471 | |||
SMC1A | embryonic-brain | TSTS | GEO | Mus musculus | GSE117184 | 3,572 | ||
SMC1A | sperm | GEO | Mus musculus | GSE79227 | 38,198 | |||
SMC1A | uterus | 1h | GEO | Mus musculus | GSE125972 | 48,090 | ||
SMC1A | uterus | Veh | GEO | Mus musculus | GSE125972 | 55,004 | ||
SMC1A | mammary-gland | delC | GEO | Mus musculus | GSE92591 | 20,354 | ||
SMC1A | mammary-gland | delA | GEO | Mus musculus | GSE92591 | 55,261 | ||
SMC1A | preadipocyte | D7 | GEO | Mus musculus | GSE95533 | 76,608 | ||
SMC1A | preadipocyte | D4 | GEO | Mus musculus | GSE95533 | 73,353 | ||
SMC1A | bone-marrow | GEO | Mus musculus | GSE83960 | 63,116 | |||
SMC1A | Th17 | GEO | Mus musculus | GSE63778 | 21,455 | |||
SMC1A | NPC | GEO | Mus musculus | GSE36203 | 52,972 | |||
SMC1A | thymocyte | GEO | Mus musculus | GSE61428 | 24,297 | |||
SMC1A | mESC | ColFRT | GEO | Mus musculus | GSE92745 | 29,904 | ||
SMC1A | HPC-7 | shStag2 | GEO | Mus musculus | GSE129478 | 41,361 | ||
SMC1A | HPC-7 | Myelo_Luc | GEO | Mus musculus | GSE129478 | 33,683 | ||
SMC1A | HPC-7 | Luc | GEO | Mus musculus | GSE129478 | 48,708 | ||
SMC1A | spleen | GEO | Mus musculus | GSE43594 | 1,398 | |||
SMC1A | spleen | stimulated | GEO | Mus musculus | GSE43594 | 9,233 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |