SMC1A

Information SMC1A

Description

Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000250}.(Source UnitProtKB).

Full Name

structural maintenance of chromosomes 1A

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
48
Biotypes
21
Peaks
1,678,563
Non-redundant peaks
397,934

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
24061
Official Gene Name
Smc1a
JASPAR
MGI
MGI:1344345
Ensembl
ENSMUSG00000041133
UniProt
Q9CU62
Genevisible
Q9CU62
RefSeq
Aliases
5830426I24Rik; SB1.8; SMC-1A; SMCB; Sb1.8; Smc1; Smc1alpha; Smc1l1; Smcb; mKIAA0178

External links
All peaks SMC1A
Download BED file
Non redundant peaks SMC1A
Download BED file
SEQUENCES SMC1A
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for SMC1A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SMC1A fibroblast Xist-del GEO Mus musculus GSE67516 33,367
SMC1A fibroblast GEO Mus musculus GSE67516 35,847
SMC1A HPC-7 Ery_Luc GEO Mus musculus GSE129478 19,768
SMC1A HPC-7 Ery_shStag2 GEO Mus musculus GSE129478 48,496
SMC1A HPC-7 shRad21 GEO Mus musculus GSE129478 24,147
SMC1A MEF GEO Mus musculus GSE32319 25,449
SMC1A MEF GEO Mus musculus GSE22562 55,749
SMC1A MEF Stag1-KO GEO Mus musculus GSE32319 50,242
SMC1A cortex GEO Mus musculus GSE42237 1,063
SMC1A embryonic-brain GEO Mus musculus GSE117184 13,085
SMC1A uterus 4h GEO Mus musculus GSE125972 53,558
SMC1A mESC Tg2a_I GEO Mus musculus GSE131356 48,668
SMC1A mESC siCtrl GEO Mus musculus GSE115340 49,959
SMC1A mESC serum GEO Mus musculus GSE92407 53,993
SMC1A mESC GEO Mus musculus GSE22562 6,374
SMC1A mESC DRC GEO Mus musculus GSE92745 11,137
SMC1A mESC EpiLSC GEO Mus musculus GSE92407 53,013
SMC1A mESC GRHL2-HA GEO Mus musculus GSE92745 11,850
SMC1A mESC 1d GEO Mus musculus GSE126362 50,713
SMC1A mESC GEO Mus musculus GSE126362 54,299
SMC1A HSPC Stag2WT GEO Mus musculus GSE138005 274
SMC1A mammary-gland WT GEO Mus musculus GSE92591 42,269
SMC1A limb GEO Mus musculus GSE42237 43,212
SMC1A distal-forelimb GEO Mus musculus GSE101714 23,991
SMC1A AtT-20 GEO Mus musculus GSE87180 8,698
SMC1A bone-marrow KO GEO Mus musculus GSE83960 45,977
SMC1A TSC CB GEO Mus musculus GSE118399 55,760
SMC1A epiblast-cell KO GEO Mus musculus GSE92745 29,004
SMC1A epiblast-cell DRC GEO Mus musculus GSE92745 11,194
SMC1A epiblast-cell GEO Mus musculus GSE92745 31,471
SMC1A embryonic-brain TSTS GEO Mus musculus GSE117184 3,572
SMC1A sperm GEO Mus musculus GSE79227 38,198
SMC1A uterus 1h GEO Mus musculus GSE125972 48,090
SMC1A uterus Veh GEO Mus musculus GSE125972 55,004
SMC1A mammary-gland delC GEO Mus musculus GSE92591 20,354
SMC1A mammary-gland delA GEO Mus musculus GSE92591 55,261
SMC1A preadipocyte D7 GEO Mus musculus GSE95533 76,608
SMC1A preadipocyte D4 GEO Mus musculus GSE95533 73,353
SMC1A bone-marrow GEO Mus musculus GSE83960 63,116
SMC1A Th17 GEO Mus musculus GSE63778 21,455
SMC1A NPC GEO Mus musculus GSE36203 52,972
SMC1A thymocyte GEO Mus musculus GSE61428 24,297
SMC1A mESC ColFRT GEO Mus musculus GSE92745 29,904
SMC1A HPC-7 shStag2 GEO Mus musculus GSE129478 41,361
SMC1A HPC-7 Myelo_Luc GEO Mus musculus GSE129478 33,683
SMC1A HPC-7 Luc GEO Mus musculus GSE129478 48,708
SMC1A spleen GEO Mus musculus GSE43594 1,398
SMC1A spleen stimulated GEO Mus musculus GSE43594 9,233
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks