SNAI1

Information SNAI1

Description

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (By similarity). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Associates with EGR1 and SP1 to mediate 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3'. In addition, may also activate the CDKN2B promoter by itself. {ECO:0000250|UniProtKB:O95863, ECO:0000269|PubMed:10655586, ECO:0000269|PubMed:11689706, ECO:0000269|PubMed:24239292}.(Source UnitProtKB).

Full Name

snail family zinc finger 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
4
Biotypes
2
Peaks
25,870
Non-redundant peaks
22,538

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
20613
Official Gene Name
Snai1
JASPAR
MGI
MGI:98330
Ensembl
ENSMUSG00000042821
UniProt
Q02085
Genevisible
Q02085
RefSeq
NM_011427
Aliases
Sna; Sna1; Snail; Snail1
All peaks SNAI1
Download BED file
Non redundant peaks SNAI1
Download BED file
SEQUENCES SNAI1
Download FASTA file
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Datasets Table for SNAI1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SNAI1 HPC-7 GEO Mus musculus GSE132990 3,186
SNAI1 HPC-7 mut GEO Mus musculus GSE132990 13,046
SNAI1 HPC-7 EV GEO Mus musculus GSE132990 151
SNAI1 myoblast GEO Mus musculus GSE24852 9,487
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks