SNAI2

Information SNAI2

Description

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250}.(Source UnitProtKB).

Full Name

snail family zinc finger 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
10,557
Non-redundant peaks
10,557

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
20583
Official Gene Name
Snai2
JASPAR
MGI
MGI:1096393
Ensembl
ENSMUSG00000022676
UniProt
P97469
Genevisible
P97469
RefSeq
NM_011415
Aliases
Slug; Slugh; Snail2
All peaks SNAI2
Download BED file
Non redundant peaks SNAI2
Download BED file
SEQUENCES SNAI2
Download FASTA file
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Datasets Table for SNAI2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SNAI2 breast-cancer GEO Mus musculus GSE61198 10,557
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks