SOX13
Information SOX13
- Description
Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:9524265, PubMed:9421502). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (PubMed:26525805). Binds to the gene promoter of MBP and acts as a transcriptional repressor (PubMed:26525805). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (PubMed:17218525, PubMed:23562159, PubMed:30413363). Required for the differentiation of Vgamma2-positive gamma-delta T-cells, a subset of IL17A expressing gamma-delta T-cells (PubMed:23562159). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (PubMed:23562159). Promotes brown adipocyte differentiation (PubMed:27923061). Inhibitor of WNT signaling (By similarity). {ECO:0000250|UniProtKB:Q9UN79, ECO:0000269|PubMed:17218525, ECO:0000269|PubMed:23562159, ECO:0000269|PubMed:26525805, ECO:0000269|PubMed:27923061, ECO:0000269|PubMed:30413363, ECO:0000269|PubMed:9421502, ECO:0000269|PubMed:9524265}.(Source UnitProtKB).
- Full Name
SRY (sex determining region Y)-box 13
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 230
- Non-redundant peaks
- 230
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR