SOX15
Information SOX15
- Description
Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (PubMed:10821863, PubMed:15863505, PubMed:16759287, PubMed:17363903). Acts as a transcriptional activator and repressor (PubMed:10821863, PubMed:15863505, PubMed:16759287). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (PubMed:15863505). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (PubMed:17363903). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (PubMed:10821863). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (PubMed:16759287). Regulates transcription of HRC via binding to it proximal enhancer region (PubMed:15863505). Involved in skeletal muscle regeneration (PubMed:15367664, PubMed:17363903). Also plays a role in the development of myogenic precursor cells (PubMed:15367664). {ECO:0000269|PubMed:10821863, ECO:0000269|PubMed:15367664, ECO:0000269|PubMed:15863505, ECO:0000269|PubMed:16759287, ECO:0000269|PubMed:17363903}.(Source UnitProtKB).
- Full Name
SRY (sex determining region Y)-box 15
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 330
- Non-redundant peaks
- 330
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
Datasets Table for SOX15
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
SOX15 | fibroblast | GEO | Mus musculus | GSE119782 | 330 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |