SOX15

Information SOX15

Description

Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (PubMed:10821863, PubMed:15863505, PubMed:16759287, PubMed:17363903). Acts as a transcriptional activator and repressor (PubMed:10821863, PubMed:15863505, PubMed:16759287). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (PubMed:15863505). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (PubMed:17363903). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (PubMed:10821863). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (PubMed:16759287). Regulates transcription of HRC via binding to it proximal enhancer region (PubMed:15863505). Involved in skeletal muscle regeneration (PubMed:15367664, PubMed:17363903). Also plays a role in the development of myogenic precursor cells (PubMed:15367664). {ECO:0000269|PubMed:10821863, ECO:0000269|PubMed:15367664, ECO:0000269|PubMed:15863505, ECO:0000269|PubMed:16759287, ECO:0000269|PubMed:17363903}.(Source UnitProtKB).

Full Name

SRY (sex determining region Y)-box 15

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
330
Non-redundant peaks
330

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
20670
Official Gene Name
Sox15
JASPAR
MGI
MGI:98363
Ensembl
ENSMUSG00000041287
UniProt
P43267
Genevisible
P43267
RefSeq
NM_009235
Aliases
All peaks SOX15
Download BED file
Non redundant peaks SOX15
Download BED file
SEQUENCES SOX15
Download FASTA file
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Datasets Table for SOX15

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SOX15 fibroblast GEO Mus musculus GSE119782 330
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks