SOX30
Information SOX30
- Description
Acts as both a transcriptional activator and repressor (PubMed:29866902, PubMed:29848638). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:29866902). Binds to its own promoter and activates its own transcription (PubMed:29866902, PubMed:29848638). Required to activate the expression of postmeiotic genes involved in spermiogenesis (PubMed:29866902, PubMed:29848638). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity). {ECO:0000250|UniProtKB:O94993, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:29848638, ECO:0000269|PubMed:29866902}.(Source UnitProtKB).
- Full Name
SRY (sex determining region Y)-box 30
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 3,991
- Non-redundant peaks
- 3,896
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 214105
- Official Gene Name
- Sox30
- JASPAR
- MGI
- MGI:1341157
- Ensembl
- ENSMUSG00000040489
- UniProt
- Q8CGW4
- Genevisible
- Q8CGW4
- RefSeq
- NM_173384
- Aliases
Datasets Table for SOX30
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SOX30 | testis | GEO | Mus musculus | GSE107644 | 2,472 | |||
| SOX30 | testis | FRT | GEO | Mus musculus | GSE107644 | 1,519 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |