SOX30

Information SOX30

Description

Acts as both a transcriptional activator and repressor (PubMed:29866902, PubMed:29848638). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:29866902). Binds to its own promoter and activates its own transcription (PubMed:29866902, PubMed:29848638). Required to activate the expression of postmeiotic genes involved in spermiogenesis (PubMed:29866902, PubMed:29848638). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity). {ECO:0000250|UniProtKB:O94993, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:29848638, ECO:0000269|PubMed:29866902}.(Source UnitProtKB).

Full Name

SRY (sex determining region Y)-box 30

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
2
Biotypes
1
Peaks
3,991
Non-redundant peaks
3,896

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
214105
Official Gene Name
Sox30
JASPAR
MGI
MGI:1341157
Ensembl
ENSMUSG00000040489
UniProt
Q8CGW4
Genevisible
Q8CGW4
RefSeq
NM_173384
Aliases
All peaks SOX30
Download BED file
Non redundant peaks SOX30
Download BED file
SEQUENCES SOX30
Download FASTA file
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Datasets Table for SOX30

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SOX30 testis GEO Mus musculus GSE107644 2,472
SOX30 testis FRT GEO Mus musculus GSE107644 1,519
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks