SOX3
Information SOX3
- Description
Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. {ECO:0000269|PubMed:14981518, ECO:0000269|PubMed:17728342, ECO:0000269|PubMed:21183788}.
- Full Name
SRY (sex determining region Y)-box 3
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 35,286
- Non-redundant peaks
- 33,007
TF Classification
- Familly
- High-mobility group (HMG) domain factors
- Sub Familly
- SOX-related factors
Source JASPAR