SP1

Information SP1

Description

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Full Name

Sp1 transcription factor

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
16
Biotypes
11
Peaks
322,491
Non-redundant peaks
178,311

TF Classification

Super Class
Zinc-coordinating DNA-binding domains
Class
C2H2 zinc finger factors
Familly
Three-zinc finger Krüppel-related factors
Sub Familly
Sp1-like factors

Source TFClass

External IDs

NCBI Gene
6667
Official Gene Name
SP1
JASPAR
MA0079
Ensembl
ENSG00000185591
UniProt
P08047
Genevisible
P08047
RefSeq
NM_001251825
Aliases
All peaks SP1
Download BED file
Non redundant peaks SP1
Download BED file
SEQUENCES SP1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for SP1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SP1 A-375 DMSO GEO Homo sapiens GSE68044 10,312
SP1 A-375 A771726 GEO Homo sapiens GSE68044 3,750
SP1 HEK293 GEO Homo sapiens GSE76494 28,768
SP1 HEK293T ENA Homo sapiens ERP007114 14,633
SP1 HL-60 ENA Homo sapiens ERP008568 199
SP1 Hep-G2 ENCODE Homo sapiens ENCSR460YAM 56,347
SP1 WA01 ENCODE Homo sapiens ENCSR000BIR 37,917
SP1 MCF-7 ENCODE Homo sapiens ENCSR729LGA 2,602
SP1 K-562 ENCODE Homo sapiens ENCSR991ELG 8,737
SP1 K-562 ENCODE Homo sapiens ENCSR000BKO 3,160
SP1 Hep-G2 ENCODE Homo sapiens ENCSR334KIQ 1,280
SP1 Hep-G2 ENCODE Homo sapiens ENCSR000BJX 30,372
SP1 A-549 ENCODE Homo sapiens ENCSR000BPE 51,356
SP1 HEK293T ENCODE Homo sapiens ENCSR906PEI 350
SP1 GM12878 ENCODE Homo sapiens ENCSR000BHK 44,555
SP1 HCT-116 ENCODE Homo sapiens ENCSR000BSF 28,153
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks