SP1
Information SP1
- Description
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
- Full Name
Sp1 transcription factor
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 16
- Biotypes
- 11
- Peaks
- 322,491
- Non-redundant peaks
- 178,311
TF Classification
- Super Class
- Zinc-coordinating DNA-binding domains
- Class
- C2H2 zinc finger factors
- Familly
- Three-zinc finger Krüppel-related factors
- Sub Familly
- Sp1-like factors
Source TFClass
External IDs
- NCBI Gene
- 6667
- Official Gene Name
- SP1
- JASPAR
- MA0079
- Ensembl
- ENSG00000185591
- UniProt
- P08047
- Genevisible
- P08047
- RefSeq
- NM_001251825
- Aliases
Datasets Table for SP1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SP1 | A-375 | DMSO | GEO | Homo sapiens | GSE68044 | 10,312 | ||
| SP1 | A-375 | A771726 | GEO | Homo sapiens | GSE68044 | 3,750 | ||
| SP1 | HEK293 | GEO | Homo sapiens | GSE76494 | 28,768 | |||
| SP1 | HEK293T | ENA | Homo sapiens | ERP007114 | 14,633 | |||
| SP1 | HL-60 | ENA | Homo sapiens | ERP008568 | 199 | |||
| SP1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR460YAM | 56,347 | |||
| SP1 | WA01 | ENCODE | Homo sapiens | ENCSR000BIR | 37,917 | |||
| SP1 | MCF-7 | ENCODE | Homo sapiens | ENCSR729LGA | 2,602 | |||
| SP1 | K-562 | ENCODE | Homo sapiens | ENCSR991ELG | 8,737 | |||
| SP1 | K-562 | ENCODE | Homo sapiens | ENCSR000BKO | 3,160 | |||
| SP1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR334KIQ | 1,280 | |||
| SP1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR000BJX | 30,372 | |||
| SP1 | A-549 | ENCODE | Homo sapiens | ENCSR000BPE | 51,356 | |||
| SP1 | HEK293T | ENCODE | Homo sapiens | ENCSR906PEI | 350 | |||
| SP1 | GM12878 | ENCODE | Homo sapiens | ENCSR000BHK | 44,555 | |||
| SP1 | HCT-116 | ENCODE | Homo sapiens | ENCSR000BSF | 28,153 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |