SPDEF

Information SPDEF

Description

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Full Name

SAM pointed domain containing ETS transcription factor

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
2
Biotypes
2
Peaks
67,189
Non-redundant peaks
63,402

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
25803
Official Gene Name
SPDEF
JASPAR
MA0686
Ensembl
ENSG00000124664
UniProt
O95238
Genevisible
O95238
RefSeq
NM_001252294
Aliases
PDEF; bA375E1.3
All peaks SPDEF
Download BED file
Non redundant peaks SPDEF
Download BED file
SEQUENCES SPDEF
Download FASTA file
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Datasets Table for SPDEF

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SPDEF MCF-7 ENCODE Homo sapiens ENCSR042GSX 55,635
SPDEF A-549 GEO Homo sapiens GSE86957 11,554
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks