SPI1

Information SPI1

Description

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

Spi-1 proto-oncogene

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
50
Biotypes
25
Peaks
1,627,779
Non-redundant peaks
335,235

TF Classification

Super Class
Helix-turn-helix domains
Class
Tryptophan cluster factors
Familly
Ets-related factors
Sub Familly
Spi-like factors

Source TFClass

External IDs

NCBI Gene
6688
Official Gene Name
SPI1
JASPAR
MA0080
Ensembl
ENSG00000066336
UniProt
P17947
Genevisible
P17947
RefSeq
NM_001080547
Aliases
OF; PU.1; SFPI1; SPI-1; SPI-A

External links
All peaks SPI1
Download BED file
Non redundant peaks SPI1
Download BED file
SEQUENCES SPI1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for SPI1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SPI1 macrophage IL4 GEO Homo sapiens GSE47188 4,934
SPI1 macrophage IFNG GEO Homo sapiens GSE47188 12,221
SPI1 macrophage D7_donorP GEO Homo sapiens GSE128834 27,190
SPI1 U-937 GEO Homo sapiens GSE128834 52,300
SPI1 CD34 FETAL GEO Homo sapiens GSE70660 65,020
SPI1 OCI-Ly7 GEO Homo sapiens GSE69558 36,118
SPI1 Ramos GEO Homo sapiens GSE139810 645
SPI1 ME-1 GEO Homo sapiens GSE46044 16,909
SPI1 THP-1 DIFF GEO Homo sapiens GSE25426 27,256
SPI1 THP-1 GEO Homo sapiens GSE128834 55,100
SPI1 monocyte MACROPHAGE GEO Homo sapiens GSE31621 43,671
SPI1 monocyte GEO Homo sapiens GSE31621 53,628
SPI1 NCI-H929 GEO Homo sapiens GSE56857 30,333
SPI1 OCI-Ly10 GEO Homo sapiens GSE56857 7,214
SPI1 Kasumi-1 SIRUNX1ETO GEO Homo sapiens GSE60130 51,841
SPI1 Kasumi-1 SICTR GEO Homo sapiens GSE60130 54,805
SPI1 NB4 GEO Homo sapiens GSE128834 45,689
SPI1 K-562 GEO Homo sapiens GSE70482 62,722
SPI1 K-562 NABUT GEO Homo sapiens GSE74999 40,349
SPI1 K-562 GEO Homo sapiens GSE74999 2,161
SPI1 K-562 SAHA GEO Homo sapiens GSE74999 10,865
SPI1 K-562 ENCODE Homo sapiens ENCSR000BGW 59,259
SPI1 GM12891 ENCODE Homo sapiens ENCSR000BIJ 55,727
SPI1 CTV-1 FLAG_15perc GEO Homo sapiens GSE128835 66,637
SPI1 CTV-1 delQ GEO Homo sapiens GSE128835 60,063
SPI1 CTV-1 delA GEO Homo sapiens GSE128835 27,472
SPI1 CTV-1 delQA GEO Homo sapiens GSE128835 42,762
SPI1 CTV-1 mock GEO Homo sapiens GSE128835 453
SPI1 EM-3 gDNA GEO Homo sapiens GSE128834 74
SPI1 EM-3 GEO Homo sapiens GSE128834 65,737
SPI1 KG-1 GEO Homo sapiens GSE128834 36,488
SPI1 OCI-Ly3 SHSPIB GEO Homo sapiens GSE56857 641
SPI1 OCI-Ly3 GEO Homo sapiens GSE56857 3,595
SPI1 OCI-Ly3 SHCTR GEO Homo sapiens GSE56857 3,030
SPI1 dendrite GEO Homo sapiens GSE58864 14,655
SPI1 BDMC donorG GEO Homo sapiens GSE128834 13,905
SPI1 BDMC donorH GEO Homo sapiens GSE128834 23,557
SPI1 primary-B-cell donorA GEO Homo sapiens GSE128834 28,666
SPI1 primary-B-cell donorC GEO Homo sapiens GSE128834 9,307
SPI1 primary-monocyte 18h_donorO GEO Homo sapiens GSE128834 51,950
SPI1 primary-monocyte 4h_donorO GEO Homo sapiens GSE128834 26,695
SPI1 primary-monocyte donorA_ncMO GEO Homo sapiens GSE128834 61,360
SPI1 primary-monocyte LPS-4h_donorO GEO Homo sapiens GSE128834 14,616
SPI1 primary-neutrophil donorF GEO Homo sapiens GSE128834 61,442
SPI1 primary-neutrophil donorE GEO Homo sapiens GSE128834 45,915
SPI1 DC LPS GEO Homo sapiens GSE123347 44,772
SPI1 DC GEO Homo sapiens GSE123347 5,607
SPI1 DC 96h_donorM GEO Homo sapiens GSE128834 74,433
SPI1 RS4-11 DEX GEO Homo sapiens GSE71616 17,789
SPI1 RS4-11 GEO Homo sapiens GSE71616 10,201
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks