SPIN1
Information SPIN1
- Description
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (By similarity). Overexpression induces metaphase arrest and chromosomal instability (PubMed:18543248). Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (PubMed:23894536). {ECO:0000250|UniProtKB:Q9Y657, ECO:0000269|PubMed:18543248, ECO:0000269|PubMed:23894536}.(Source UnitProtKB).
- Full Name
spindlin 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 16,781
- Non-redundant peaks
- 16,781
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 20729
- Official Gene Name
- Spin1
- JASPAR
- MGI
- MGI:109242
- Ensembl
- ENSMUSG00000021395
- UniProt
- Q61142
- Genevisible
- Q61142
- RefSeq
- NM_146043
- Aliases
- Spin
Datasets Table for SPIN1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SPIN1 | skeletal-muscle | GEO | Mus musculus | GSE92539 | 16,781 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |