SREBF1
Information SREBF1
- Description
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
- Full Name
sterol regulatory element binding transcription factor 1
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 8
- Biotypes
- 7
- Peaks
- 29,866
- Non-redundant peaks
- 22,520
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- bHLH-ZIP factors
- Sub Familly
- SREBP factors
Source TFClass
External IDs
- NCBI Gene
- 6720
- Official Gene Name
- SREBF1
- JASPAR
- MA0595
- Ensembl
- ENSG00000072310
- UniProt
- P36956
- Genevisible
- P36956
- RefSeq
- NM_001005291
- Aliases
- SREBP-1c; SREBP1; SREBP1a; bHLHd1
Datasets Table for SREBF1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SREBF1 | TE-5 | GEO | Homo sapiens | GSE143803 | 2,472 | |||
| SREBF1 | KYSE-150 | GEO | Homo sapiens | GSE143803 | 1,733 | |||
| SREBF1 | MCF-7 | ENCODE | Homo sapiens | ENCSR197DJH | 5,571 | |||
| SREBF1 | K-562 | ENCODE | Homo sapiens | ENCSR815ZDS | 12,831 | |||
| SREBF1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR000EEO | 1,466 | |||
| SREBF1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR000EZP | 273 | |||
| SREBF1 | A-549 | ENCODE | Homo sapiens | ENCSR897MYK | 4,004 | |||
| SREBF1 | GM12878 | ENCODE | Homo sapiens | ENCSR000DYU | 1,516 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |