SRF
Information SRF
- Description
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS) (PubMed:24732378). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12732141, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). Required for cardiac differentiation and maturation (PubMed:15169892). {ECO:0000269|PubMed:12732141, ECO:0000269|PubMed:15169892, ECO:0000269|PubMed:19350017, ECO:0000269|PubMed:24732378}.(Source UnitProtKB).
- Full Name
serum response factor
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 25
- Biotypes
- 11
- Peaks
- 624,540
- Non-redundant peaks
- 251,404
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 20807
- Official Gene Name
- Srf
- JASPAR
- MGI
- MGI:106658
- Ensembl
- ENSMUSG00000015605
- UniProt
- Q9JM73
- Genevisible
- Q9JM73
- RefSeq
- NM_020493
- Aliases
- AW049942; AW240594
Datasets Table for SRF
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SRF | myocyte | ENCODE | Mus musculus | ENCSR000AIM | 1,261 | |||
| SRF | mut | cornea | mut | GEO | Mus musculus | GSE54209 | 41,180 | |
| SRF | MEF | GEO | Mus musculus | GSE71708 | 477 | |||
| SRF | MEF | GEO | Mus musculus | GSE75667 | 19,412 | |||
| SRF | MEF | 12min | GEO | Mus musculus | GSE71708 | 8,406 | ||
| SRF | VSMC | P10 | GEO | Mus musculus | GSE112417 | 79,369 | ||
| SRF | VSMC | P1 | GEO | Mus musculus | GSE112417 | 65,664 | ||
| SRF | iPSC | blocked_sc | GEO | Mus musculus | GSE120399 | 19,631 | ||
| SRF | iPSC | ctrl_sc | GEO | Mus musculus | GSE120399 | 15,692 | ||
| SRF | C3H-10T1-2 | GEO | Mus musculus | GSE40369 | 43,371 | |||
| SRF | hepatoblast | GEO | Mus musculus | GSE106319 | 3,207 | |||
| SRF | heart | post-natal-D42 | GEO | Mus musculus | GSE109504 | 10,252 | ||
| SRF | heart | GEO | Mus musculus | GSE19065 | 5,034 | |||
| SRF | HL-1 | GEO | Mus musculus | GSE21529 | 12,871 | |||
| SRF | BMDM | GEO | Mus musculus | GSE67343 | 599 | |||
| SRF | BMDM | lipidA-1h | GEO | Mus musculus | GSE67343 | 387 | ||
| SRF | VSMC | GEO | Mus musculus | GSE112417 | 70,682 | |||
| SRF | cornea | GEO | Mus musculus | GSE54209 | 49,779 | |||
| SRF | heart | post-natal-D14 | GEO | Mus musculus | GSE109504 | 32,099 | ||
| SRF | MEF | Tcf-KO | GEO | Mus musculus | GSE75667 | 15,250 | ||
| SRF | MEF | Tcf-KO_TPA | GEO | Mus musculus | GSE75667 | 5,009 | ||
| SRF | MEF | TPA | GEO | Mus musculus | GSE75667 | 8,902 | ||
| SRF | NPC | GEO | Mus musculus | GSE106319 | 1,957 | |||
| SRF | NPC | overexpression | GEO | Mus musculus | GSE106319 | 72,259 | ||
| SRF | C3H-10T1-2 | si23 | GEO | Mus musculus | GSE40369 | 41,790 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |