SRF

Information SRF

Description

SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS) (PubMed:24732378). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12732141, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). Required for cardiac differentiation and maturation (PubMed:15169892). {ECO:0000269|PubMed:12732141, ECO:0000269|PubMed:15169892, ECO:0000269|PubMed:19350017, ECO:0000269|PubMed:24732378}.(Source UnitProtKB).

Full Name

serum response factor

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
25
Biotypes
11
Peaks
624,540
Non-redundant peaks
251,404

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
20807
Official Gene Name
Srf
JASPAR
MGI
MGI:106658
Ensembl
ENSMUSG00000015605
UniProt
Q9JM73
Genevisible
Q9JM73
RefSeq
NM_020493
Aliases
AW049942; AW240594
All peaks SRF
Download BED file
Non redundant peaks SRF
Download BED file
SEQUENCES SRF
Download FASTA file
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Datasets Table for SRF

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SRF myocyte ENCODE Mus musculus ENCSR000AIM 1,261
SRF mut cornea mut GEO Mus musculus GSE54209 41,180
SRF MEF GEO Mus musculus GSE71708 477
SRF MEF GEO Mus musculus GSE75667 19,412
SRF MEF 12min GEO Mus musculus GSE71708 8,406
SRF VSMC P10 GEO Mus musculus GSE112417 79,369
SRF VSMC P1 GEO Mus musculus GSE112417 65,664
SRF iPSC blocked_sc GEO Mus musculus GSE120399 19,631
SRF iPSC ctrl_sc GEO Mus musculus GSE120399 15,692
SRF C3H-10T1-2 GEO Mus musculus GSE40369 43,371
SRF hepatoblast GEO Mus musculus GSE106319 3,207
SRF heart post-natal-D42 GEO Mus musculus GSE109504 10,252
SRF heart GEO Mus musculus GSE19065 5,034
SRF HL-1 GEO Mus musculus GSE21529 12,871
SRF BMDM GEO Mus musculus GSE67343 599
SRF BMDM lipidA-1h GEO Mus musculus GSE67343 387
SRF VSMC GEO Mus musculus GSE112417 70,682
SRF cornea GEO Mus musculus GSE54209 49,779
SRF heart post-natal-D14 GEO Mus musculus GSE109504 32,099
SRF MEF Tcf-KO GEO Mus musculus GSE75667 15,250
SRF MEF Tcf-KO_TPA GEO Mus musculus GSE75667 5,009
SRF MEF TPA GEO Mus musculus GSE75667 8,902
SRF NPC GEO Mus musculus GSE106319 1,957
SRF NPC overexpression GEO Mus musculus GSE106319 72,259
SRF C3H-10T1-2 si23 GEO Mus musculus GSE40369 41,790
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks