SSRP1

Information SSRP1

Description

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]

Full Name

structure specific recognition protein 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
4
Biotypes
3
Peaks
40,323
Non-redundant peaks
38,937

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
6749
Official Gene Name
SSRP1
JASPAR
Ensembl
ENSG00000149136
UniProt
Q08945
Genevisible
Q08945
RefSeq
NM_003146
Aliases
FACT; FACT80; T160
All peaks SSRP1
Download BED file
Non redundant peaks SSRP1
Download BED file
SEQUENCES SSRP1
Download FASTA file
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Datasets Table for SSRP1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SSRP1 HT-1080 AclacinomycinA GEO Homo sapiens GSE107595 5,819
SSRP1 HT-1080 CBL0100 GEO Homo sapiens GSE107595 5,496
SSRP1 Hep-G2 ENCODE Homo sapiens ENCSR571PDN 23,382
SSRP1 hiF-T GEO Homo sapiens GSE98758 5,626
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks