STAT1
Information STAT1
- Description
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. {ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:9344858}.
- Full Name
signal transducer and activator of transcription 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 60
- Biotypes
- 11
- Peaks
- 1,238,921
- Non-redundant peaks
- 255,556
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 20846
- Official Gene Name
- Stat1
- JASPAR
- MGI
- MGI:103063
- Ensembl
- ENSMUSG00000026104
- UniProt
- P42225
- Genevisible
- P42225
- RefSeq
- NM_009283
- Aliases
- 2010005J02Rik; AA408197
Datasets Table for STAT1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
STAT1 | spleen | GEO | Mus musculus | GSE51531 | 23,754 | |||
STAT1 | Th1 | GEO | Mus musculus | GSE40463 | 56,283 | |||
STAT1 | CD4-pos | S3-KO | GEO | Mus musculus | GSE63204 | 21,514 | ||
STAT1 | CD4-pos | S3-KO_IL21 | GEO | Mus musculus | GSE63204 | 27,559 | ||
STAT1 | CD4-pos | Stat3-KO_IL27 | GEO | Mus musculus | GSE65621 | 4,713 | ||
STAT1 | CD4-pos | IL21 | GEO | Mus musculus | GSE63204 | 21,447 | ||
STAT1 | CD4-pos | IL27 | GEO | Mus musculus | GSE65621 | 8,801 | ||
STAT1 | CD4-pos | nc_Tbet-KO | GEO | Mus musculus | GSE96724 | 1,394 | ||
STAT1 | CD4-pos | IFN-g_Tbet-KO | GEO | Mus musculus | GSE96724 | 2,311 | ||
STAT1 | CD4-pos | nc | GEO | Mus musculus | GSE96724 | 1,155 | ||
STAT1 | CD4-pos | Stat3-KO | GEO | Mus musculus | GSE65621 | 2,980 | ||
STAT1 | MEF | GEO | Mus musculus | GSE128107 | 133 | |||
STAT1 | aorta | VSMC_IFNa-LPS | GEO | Mus musculus | GSE120806 | 19,111 | ||
STAT1 | aorta | VSMC_LPS | GEO | Mus musculus | GSE120806 | 13,773 | ||
STAT1 | B-cell | IFN | GEO | Mus musculus | GSE75250 | 1,321 | ||
STAT1 | CD8-pos | plC | GEO | Mus musculus | GSE106730 | 14,483 | ||
STAT1 | 3T3-L1 | GEO | Mus musculus | GSE56872 | 20,344 | |||
STAT1 | BMM | IFNb_Ikk-neg | GEO | Mus musculus | GSE33913 | 59,745 | ||
STAT1 | BMM | Ikk-neg | GEO | Mus musculus | GSE33913 | 63,945 | ||
STAT1 | BMM | IFNg_Ikk-neg | GEO | Mus musculus | GSE33913 | 63,711 | ||
STAT1 | BMDM | IFNb | GEO | Mus musculus | GSE115433 | 17,827 | ||
STAT1 | BMDM | IFNg-4h | GEO | Mus musculus | GSE84518 | 19,018 | ||
STAT1 | BMDM | IFNg-2h | GEO | Mus musculus | GSE84518 | 35,690 | ||
STAT1 | BMDM | IFN | GEO | Mus musculus | GSE56121 | 17,352 | ||
STAT1 | BMDM | GEO | Mus musculus | GSE84518 | 25,765 | |||
STAT1 | BMDM | IFN-1h | GEO | Mus musculus | GSE56121 | 20,894 | ||
STAT1 | BMDM | Irf9-KO | GEO | Mus musculus | GSE115433 | 148 | ||
STAT1 | BMDM | IFNg_1h | GEO | Mus musculus | GSE38377 | 20,357 | ||
STAT1 | BMDM | LPS-4h | GEO | Mus musculus | GSE38377 | 5,118 | ||
STAT1 | BMDM | IFNg_Irf9-KO | GEO | Mus musculus | GSE115433 | 14,551 | ||
STAT1 | BMDM | IFNg_30min | GEO | Mus musculus | GSE38377 | 24,298 | ||
STAT1 | BMDM | IFNg | GEO | Mus musculus | GSE115433 | 14,924 | ||
STAT1 | BMM | IFNb | GEO | Mus musculus | GSE33913 | 75,740 | ||
STAT1 | BMM | IFNg | GEO | Mus musculus | GSE33913 | 65,090 | ||
STAT1 | BMM | GEO | Mus musculus | GSE33913 | 61,189 | |||
STAT1 | CD4-pos | GEO | Mus musculus | GSE63204 | 10,392 | |||
STAT1 | CD4-pos | IL6 | GEO | Mus musculus | GSE65621 | 11,179 | ||
STAT1 | CD4-pos | Stat3-KO_IL6 | GEO | Mus musculus | GSE65621 | 1,907 | ||
STAT1 | CD4-pos | IFN-b_Tbet-KO | GEO | Mus musculus | GSE96724 | 1,878 | ||
STAT1 | CD4-pos | IFN-b | GEO | Mus musculus | GSE96724 | 1,564 | ||
STAT1 | CD4-pos | IFN-g | GEO | Mus musculus | GSE96724 | 350 | ||
STAT1 | CD4-pos | GEO | Mus musculus | GSE65621 | 3,654 | |||
STAT1 | aorta | VSMC_IFNg-LPS | GEO | Mus musculus | GSE120806 | 62,825 | ||
STAT1 | aorta | VSMC | GEO | Mus musculus | GSE120806 | 1,661 | ||
STAT1 | aorta | VSMC_IFNa | GEO | Mus musculus | GSE120806 | 20,876 | ||
STAT1 | aorta | VSMC_IFNg | GEO | Mus musculus | GSE120806 | 51,807 | ||
STAT1 | BMDM | IFNb_Irf9-KO | GEO | Mus musculus | GSE115433 | 17,918 | ||
STAT1 | BMDM | BXH2_IFN-30m | GEO | Mus musculus | GSE56121 | 40,611 | ||
STAT1 | BMDM | IFNg_2h | GEO | Mus musculus | GSE38377 | 13,260 | ||
STAT1 | BMDM | LPS-2h | GEO | Mus musculus | GSE56121 | 17,129 | ||
STAT1 | BMDM | BXH2_IFN-1h | GEO | Mus musculus | GSE56121 | 28,547 | ||
STAT1 | BMDM | UT | GEO | Mus musculus | GSE84518 | 6,025 | ||
STAT1 | BMDM | BXH2 | GEO | Mus musculus | GSE56121 | 14,880 | ||
STAT1 | BMDM | IFN-30m | GEO | Mus musculus | GSE56121 | 38,832 | ||
STAT1 | BMDM | IL4 | GEO | Mus musculus | GSE84518 | 26,934 | ||
STAT1 | B-cell | GEO | Mus musculus | GSE75250 | 1,182 | |||
STAT1 | CD8-pos | GEO | Mus musculus | GSE106730 | 4,386 | |||
STAT1 | CD8-pos | CpG | GEO | Mus musculus | GSE106730 | 11,065 | ||
STAT1 | HPC-7 | TPO-30min | GEO | Mus musculus | GSE100835 | 3,162 | ||
STAT1 | HPC-7 | serum-starved | GEO | Mus musculus | GSE100835 | 459 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |