STAT1

Information STAT1

Description

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. {ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:9344858}.

Full Name

signal transducer and activator of transcription 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
60
Biotypes
11
Peaks
1,238,921
Non-redundant peaks
255,556

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
20846
Official Gene Name
Stat1
JASPAR
MGI
MGI:103063
Ensembl
ENSMUSG00000026104
UniProt
P42225
Genevisible
P42225
RefSeq
NM_009283
Aliases
2010005J02Rik; AA408197
All peaks STAT1
Download BED file
Non redundant peaks STAT1
Download BED file
SEQUENCES STAT1
Download FASTA file
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Datasets Table for STAT1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
STAT1 spleen GEO Mus musculus GSE51531 23,754
STAT1 Th1 GEO Mus musculus GSE40463 56,283
STAT1 CD4-pos S3-KO GEO Mus musculus GSE63204 21,514
STAT1 CD4-pos S3-KO_IL21 GEO Mus musculus GSE63204 27,559
STAT1 CD4-pos Stat3-KO_IL27 GEO Mus musculus GSE65621 4,713
STAT1 CD4-pos IL21 GEO Mus musculus GSE63204 21,447
STAT1 CD4-pos IL27 GEO Mus musculus GSE65621 8,801
STAT1 CD4-pos nc_Tbet-KO GEO Mus musculus GSE96724 1,394
STAT1 CD4-pos IFN-g_Tbet-KO GEO Mus musculus GSE96724 2,311
STAT1 CD4-pos nc GEO Mus musculus GSE96724 1,155
STAT1 CD4-pos Stat3-KO GEO Mus musculus GSE65621 2,980
STAT1 MEF GEO Mus musculus GSE128107 133
STAT1 aorta VSMC_IFNa-LPS GEO Mus musculus GSE120806 19,111
STAT1 aorta VSMC_LPS GEO Mus musculus GSE120806 13,773
STAT1 B-cell IFN GEO Mus musculus GSE75250 1,321
STAT1 CD8-pos plC GEO Mus musculus GSE106730 14,483
STAT1 3T3-L1 GEO Mus musculus GSE56872 20,344
STAT1 BMM IFNb_Ikk-neg GEO Mus musculus GSE33913 59,745
STAT1 BMM Ikk-neg GEO Mus musculus GSE33913 63,945
STAT1 BMM IFNg_Ikk-neg GEO Mus musculus GSE33913 63,711
STAT1 BMDM IFNb GEO Mus musculus GSE115433 17,827
STAT1 BMDM IFNg-4h GEO Mus musculus GSE84518 19,018
STAT1 BMDM IFNg-2h GEO Mus musculus GSE84518 35,690
STAT1 BMDM IFN GEO Mus musculus GSE56121 17,352
STAT1 BMDM GEO Mus musculus GSE84518 25,765
STAT1 BMDM IFN-1h GEO Mus musculus GSE56121 20,894
STAT1 BMDM Irf9-KO GEO Mus musculus GSE115433 148
STAT1 BMDM IFNg_1h GEO Mus musculus GSE38377 20,357
STAT1 BMDM LPS-4h GEO Mus musculus GSE38377 5,118
STAT1 BMDM IFNg_Irf9-KO GEO Mus musculus GSE115433 14,551
STAT1 BMDM IFNg_30min GEO Mus musculus GSE38377 24,298
STAT1 BMDM IFNg GEO Mus musculus GSE115433 14,924
STAT1 BMM IFNb GEO Mus musculus GSE33913 75,740
STAT1 BMM IFNg GEO Mus musculus GSE33913 65,090
STAT1 BMM GEO Mus musculus GSE33913 61,189
STAT1 CD4-pos GEO Mus musculus GSE63204 10,392
STAT1 CD4-pos IL6 GEO Mus musculus GSE65621 11,179
STAT1 CD4-pos Stat3-KO_IL6 GEO Mus musculus GSE65621 1,907
STAT1 CD4-pos IFN-b_Tbet-KO GEO Mus musculus GSE96724 1,878
STAT1 CD4-pos IFN-b GEO Mus musculus GSE96724 1,564
STAT1 CD4-pos IFN-g GEO Mus musculus GSE96724 350
STAT1 CD4-pos GEO Mus musculus GSE65621 3,654
STAT1 aorta VSMC_IFNg-LPS GEO Mus musculus GSE120806 62,825
STAT1 aorta VSMC GEO Mus musculus GSE120806 1,661
STAT1 aorta VSMC_IFNa GEO Mus musculus GSE120806 20,876
STAT1 aorta VSMC_IFNg GEO Mus musculus GSE120806 51,807
STAT1 BMDM IFNb_Irf9-KO GEO Mus musculus GSE115433 17,918
STAT1 BMDM BXH2_IFN-30m GEO Mus musculus GSE56121 40,611
STAT1 BMDM IFNg_2h GEO Mus musculus GSE38377 13,260
STAT1 BMDM LPS-2h GEO Mus musculus GSE56121 17,129
STAT1 BMDM BXH2_IFN-1h GEO Mus musculus GSE56121 28,547
STAT1 BMDM UT GEO Mus musculus GSE84518 6,025
STAT1 BMDM BXH2 GEO Mus musculus GSE56121 14,880
STAT1 BMDM IFN-30m GEO Mus musculus GSE56121 38,832
STAT1 BMDM IL4 GEO Mus musculus GSE84518 26,934
STAT1 B-cell GEO Mus musculus GSE75250 1,182
STAT1 CD8-pos GEO Mus musculus GSE106730 4,386
STAT1 CD8-pos CpG GEO Mus musculus GSE106730 11,065
STAT1 HPC-7 TPO-30min GEO Mus musculus GSE100835 3,162
STAT1 HPC-7 serum-starved GEO Mus musculus GSE100835 459
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks