STAT1

Information STAT1

Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]

Full Name

signal transducer and activator of transcription 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
19
Biotypes
9
Peaks
378,643
Non-redundant peaks
201,729

TF Classification

Super Class
Immunoglobulin fold
Class
STAT domain factors
Familly
STAT factors
Sub Familly
None

Source TFClass

External IDs

NCBI Gene
6772
Official Gene Name
STAT1
JASPAR
MA0517
Ensembl
ENSG00000115415
UniProt
P42224
Genevisible
P42224
RefSeq
NM_007315
Aliases
CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91

External links
All peaks STAT1
Download BED file
Non redundant peaks STAT1
Download BED file
SEQUENCES STAT1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for STAT1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
STAT1 CD14 INFG_LPS GEO Homo sapiens GSE43036 67,339
STAT1 CD14 INFG GEO Homo sapiens GSE43036 57,671
STAT1 CD14 LPS GEO Homo sapiens GSE43036 49,125
STAT1 CD14 GEO Homo sapiens GSE43036 10,636
STAT1 FaDu BB608 GEO Homo sapiens GSE78212 17,823
STAT1 FaDu DMSO GEO Homo sapiens GSE78212 17,466
STAT1 AGS GEO Homo sapiens GSE79707 1,449
STAT1 SET-2 DMSO GEO Homo sapiens GSE100566 25,449
STAT1 pS727 SET-2 GEO Homo sapiens GSE100566 71,337
STAT1 SET-2 cortistatin-A GEO Homo sapiens GSE100566 13,397
STAT1 THP-1 IFNb GEO Homo sapiens GSE128111 1,766
STAT1 THP-1 GEO Homo sapiens GSE128111 1,082
STAT1 K-562 ENCODE Homo sapiens ENCSR000FAU 871
STAT1 K-562 ENCODE Homo sapiens ENCSR000EHK 1,266
STAT1 K-562 ENCODE Homo sapiens ENCSR000FAV 592
STAT1 K-562 ENCODE Homo sapiens ENCSR000EHJ 2,434
STAT1 GM12878 ENCODE Homo sapiens ENCSR332EYT 5,374
STAT1 NCI-H358 GEO Homo sapiens GSE79707 15,445
STAT1 HeLa-S3 ENCODE Homo sapiens ENCSR000EZK 18,121
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks