STAT2
Information STAT2
- Description
Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively. {ECO:0000250|UniProtKB:P52630}.
- Full Name
signal transducer and activator of transcription 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 15
- Biotypes
- 5
- Peaks
- 134,453
- Non-redundant peaks
- 65,501
TF Classification
- Familly
- STAT domain factors
- Sub Familly
- STAT factors
Source JASPAR
External IDs
- NCBI Gene
- 20847
- Official Gene Name
- Stat2
- JASPAR
- MA1623.1
- MGI
- MGI:103039
- Ensembl
- ENSMUSG00000040033
- UniProt
- Q9WVL2
- Genevisible
- Q9WVL2
- RefSeq
- NM_019963
- Aliases
- 1600010G07Rik; AW496480
Datasets Table for STAT2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| STAT2 | CD4-pos | IFN-b_Tbet-KO | GEO | Mus musculus | GSE96724 | 16,106 | ||
| STAT2 | CD4-pos | IFN-g | GEO | Mus musculus | GSE96724 | 4,028 | ||
| STAT2 | CD4-pos | IFN-b | GEO | Mus musculus | GSE96724 | 13,817 | ||
| STAT2 | CD4-pos | nc_Tbet-KO | GEO | Mus musculus | GSE96724 | 5,365 | ||
| STAT2 | CD4-pos | IFN-g_Tbet-KO | GEO | Mus musculus | GSE96724 | 5,915 | ||
| STAT2 | BMDC | 30min | GEO | Mus musculus | GSE36099 | 105 | ||
| STAT2 | B-cell | IFN | GEO | Mus musculus | GSE75250 | 7,318 | ||
| STAT2 | B-cell | GEO | Mus musculus | GSE75250 | 802 | |||
| STAT2 | BMDM | IFNg | GEO | Mus musculus | GSE115433 | 6,660 | ||
| STAT2 | BMDM | IFNb | GEO | Mus musculus | GSE115433 | 32,387 | ||
| STAT2 | BMDM | Irf9-KO | GEO | Mus musculus | GSE115433 | 317 | ||
| STAT2 | CD4-pos | nc | GEO | Mus musculus | GSE96724 | 5,871 | ||
| STAT2 | BMDM | IFNb_Irf9-KO | GEO | Mus musculus | GSE115433 | 32,899 | ||
| STAT2 | MEF | GEO | Mus musculus | GSE128107 | 269 | |||
| STAT2 | MEF | IFNb-90min | GEO | Mus musculus | GSE128107 | 2,594 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |