STAT3

Information STAT3

Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

Full Name

signal transducer and activator of transcription 3

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
49
Biotypes
14
Peaks
752,365
Non-redundant peaks
237,559

TF Classification

Familly
STAT domain factors
Sub Familly
STAT factors

Source JASPAR

External IDs

NCBI Gene
20848
Official Gene Name
Stat3
JASPAR
MA0144.1
MGI
MGI:103038
Ensembl
ENSMUSG00000004040
UniProt
P42227
Genevisible
P42227
RefSeq
NM_213660
Aliases
1110034C02Rik; AW109958; Aprf
All peaks STAT3
Download BED file
Non redundant peaks STAT3
Download BED file
SEQUENCES STAT3
Download FASTA file
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Datasets Table for STAT3

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
STAT3 CD4-pos GEO Mus musculus GSE63204 7,305
STAT3 CD4-pos S1-KO GEO Mus musculus GSE63204 7,625
STAT3 CD4-pos IL27_Stat1-KO GEO Mus musculus GSE65621 32,808
STAT3 CD4-pos IL6 GEO Mus musculus GSE65621 24,269
STAT3 CD4-pos S1-KO_IL21 GEO Mus musculus GSE63204 11,283
STAT3 CD4-pos Stat1-KO GEO Mus musculus GSE65621 12,621
STAT3 CD4-pos GEO Mus musculus GSE65621 9,894
STAT3 CD4-pos IL21 GEO Mus musculus GSE63204 11,616
STAT3 CD4-pos GEO Mus musculus GSE61677 7,295
STAT3 CD4-pos GEO Mus musculus GSE23681 609
STAT3 CD4-pos IL21 GEO Mus musculus GSE61677 11,626
STAT3 OLP GEO Mus musculus GSE99708 33,171
STAT3 primary-hepatocyte IL-6_DN-NFkB GEO Mus musculus GSE96767 2,262
STAT3 primary-hepatocyte IL-1_DN-NFkB GEO Mus musculus GSE96767 264
STAT3 gastric-tumor IL6 GEO Mus musculus GSE48285 891
STAT3 gastric-tumor IL6 GEO Mus musculus GSE48287 890
STAT3 BMDC 2h GEO Mus musculus GSE36099 8,787
STAT3 macrophage IL10 GEO Mus musculus GSE31529 130
STAT3 Th17 GEO Mus musculus GSE40918 7,282
STAT3 Th17 Rorc-WT GEO Mus musculus GSE40918 50,311
STAT3 Th17 3h GEO Mus musculus GSE40918 12,714
STAT3 Th17 Rorc-KO GEO Mus musculus GSE40918 39,488
STAT3 PHOSPHO Th17 GEO Mus musculus GSE21669 51,001
STAT3 kidney E12-Ramp3 GEO Mus musculus GSE115368 17,899
STAT3 mammary-gland I24 GEO Mus musculus GSE84115 55,408
STAT3 mammary-gland L1 GEO Mus musculus GSE84115 23,923
STAT3 mammary-gland I12 GEO Mus musculus GSE84115 33,963
STAT3 AtT-20 LIF GEO Mus musculus GSE37235 6,490
STAT3 Th0 GEO Mus musculus GSE40918 449
STAT3 BMDM GEO Mus musculus GSE86169 132
STAT3 BMDM LPS GEO Mus musculus GSE86169 117
STAT3 BMDM IL10 GEO Mus musculus GSE86169 3,163
STAT3 BMDM LPS_IL10 GEO Mus musculus GSE86169 4,482
STAT3 CD34 GEO Mus musculus GSE100689 335
STAT3 primary-hepatocyte IL-6 GEO Mus musculus GSE96767 1,231
STAT3 primary-hepatocyte dual GEO Mus musculus GSE96767 596
STAT3 primary-hepatocyte dual_DN-NFkB GEO Mus musculus GSE96767 1,111
STAT3 CD4-pos IL27 GEO Mus musculus GSE65621 28,189
STAT3 CD4-pos IL6_Stat1-KO GEO Mus musculus GSE65621 35,237
STAT3 astrocyte GEO Mus musculus GSE51281 240
STAT3 Th17 16h GEO Mus musculus GSE40918 14,680
STAT3 Th17 GEO Mus musculus GSE39756 27,347
STAT3 gastric-tumor IL11 GEO Mus musculus GSE48287 616
STAT3 gastric-tumor IL11 GEO Mus musculus GSE48285 618
STAT3 AtT-20 Pax7 GEO Mus musculus GSE87180 35,205
STAT3 AtT-20 ERPax7 GEO Mus musculus GSE87180 28,181
STAT3 AtT-20 Dex_LIF GEO Mus musculus GSE37235 6,604
STAT3 AtT-20 GEO Mus musculus GSE87180 59,664
STAT3 AtT-20 ERPax7_stable GEO Mus musculus GSE87180 22,343
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks