STAT3
Information STAT3
- Description
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
- Full Name
signal transducer and activator of transcription 3
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 49
- Biotypes
- 14
- Peaks
- 752,365
- Non-redundant peaks
- 237,559
TF Classification
- Familly
- STAT domain factors
- Sub Familly
- STAT factors
Source JASPAR
External IDs
- NCBI Gene
- 20848
- Official Gene Name
- Stat3
- JASPAR
- MA0144.1
- MGI
- MGI:103038
- Ensembl
- ENSMUSG00000004040
- UniProt
- P42227
- Genevisible
- P42227
- RefSeq
- NM_213660
- Aliases
- 1110034C02Rik; AW109958; Aprf
Datasets Table for STAT3
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
STAT3 | CD4-pos | GEO | Mus musculus | GSE63204 | 7,305 | |||
STAT3 | CD4-pos | S1-KO | GEO | Mus musculus | GSE63204 | 7,625 | ||
STAT3 | CD4-pos | IL27_Stat1-KO | GEO | Mus musculus | GSE65621 | 32,808 | ||
STAT3 | CD4-pos | IL6 | GEO | Mus musculus | GSE65621 | 24,269 | ||
STAT3 | CD4-pos | S1-KO_IL21 | GEO | Mus musculus | GSE63204 | 11,283 | ||
STAT3 | CD4-pos | Stat1-KO | GEO | Mus musculus | GSE65621 | 12,621 | ||
STAT3 | CD4-pos | GEO | Mus musculus | GSE65621 | 9,894 | |||
STAT3 | CD4-pos | IL21 | GEO | Mus musculus | GSE63204 | 11,616 | ||
STAT3 | CD4-pos | GEO | Mus musculus | GSE61677 | 7,295 | |||
STAT3 | CD4-pos | GEO | Mus musculus | GSE23681 | 609 | |||
STAT3 | CD4-pos | IL21 | GEO | Mus musculus | GSE61677 | 11,626 | ||
STAT3 | OLP | GEO | Mus musculus | GSE99708 | 33,171 | |||
STAT3 | primary-hepatocyte | IL-6_DN-NFkB | GEO | Mus musculus | GSE96767 | 2,262 | ||
STAT3 | primary-hepatocyte | IL-1_DN-NFkB | GEO | Mus musculus | GSE96767 | 264 | ||
STAT3 | gastric-tumor | IL6 | GEO | Mus musculus | GSE48285 | 891 | ||
STAT3 | gastric-tumor | IL6 | GEO | Mus musculus | GSE48287 | 890 | ||
STAT3 | BMDC | 2h | GEO | Mus musculus | GSE36099 | 8,787 | ||
STAT3 | macrophage | IL10 | GEO | Mus musculus | GSE31529 | 130 | ||
STAT3 | Th17 | GEO | Mus musculus | GSE40918 | 7,282 | |||
STAT3 | Th17 | Rorc-WT | GEO | Mus musculus | GSE40918 | 50,311 | ||
STAT3 | Th17 | 3h | GEO | Mus musculus | GSE40918 | 12,714 | ||
STAT3 | Th17 | Rorc-KO | GEO | Mus musculus | GSE40918 | 39,488 | ||
STAT3 | PHOSPHO | Th17 | GEO | Mus musculus | GSE21669 | 51,001 | ||
STAT3 | kidney | E12-Ramp3 | GEO | Mus musculus | GSE115368 | 17,899 | ||
STAT3 | mammary-gland | I24 | GEO | Mus musculus | GSE84115 | 55,408 | ||
STAT3 | mammary-gland | L1 | GEO | Mus musculus | GSE84115 | 23,923 | ||
STAT3 | mammary-gland | I12 | GEO | Mus musculus | GSE84115 | 33,963 | ||
STAT3 | AtT-20 | LIF | GEO | Mus musculus | GSE37235 | 6,490 | ||
STAT3 | Th0 | GEO | Mus musculus | GSE40918 | 449 | |||
STAT3 | BMDM | GEO | Mus musculus | GSE86169 | 132 | |||
STAT3 | BMDM | LPS | GEO | Mus musculus | GSE86169 | 117 | ||
STAT3 | BMDM | IL10 | GEO | Mus musculus | GSE86169 | 3,163 | ||
STAT3 | BMDM | LPS_IL10 | GEO | Mus musculus | GSE86169 | 4,482 | ||
STAT3 | CD34 | GEO | Mus musculus | GSE100689 | 335 | |||
STAT3 | primary-hepatocyte | IL-6 | GEO | Mus musculus | GSE96767 | 1,231 | ||
STAT3 | primary-hepatocyte | dual | GEO | Mus musculus | GSE96767 | 596 | ||
STAT3 | primary-hepatocyte | dual_DN-NFkB | GEO | Mus musculus | GSE96767 | 1,111 | ||
STAT3 | CD4-pos | IL27 | GEO | Mus musculus | GSE65621 | 28,189 | ||
STAT3 | CD4-pos | IL6_Stat1-KO | GEO | Mus musculus | GSE65621 | 35,237 | ||
STAT3 | astrocyte | GEO | Mus musculus | GSE51281 | 240 | |||
STAT3 | Th17 | 16h | GEO | Mus musculus | GSE40918 | 14,680 | ||
STAT3 | Th17 | GEO | Mus musculus | GSE39756 | 27,347 | |||
STAT3 | gastric-tumor | IL11 | GEO | Mus musculus | GSE48287 | 616 | ||
STAT3 | gastric-tumor | IL11 | GEO | Mus musculus | GSE48285 | 618 | ||
STAT3 | AtT-20 | Pax7 | GEO | Mus musculus | GSE87180 | 35,205 | ||
STAT3 | AtT-20 | ERPax7 | GEO | Mus musculus | GSE87180 | 28,181 | ||
STAT3 | AtT-20 | Dex_LIF | GEO | Mus musculus | GSE37235 | 6,604 | ||
STAT3 | AtT-20 | GEO | Mus musculus | GSE87180 | 59,664 | |||
STAT3 | AtT-20 | ERPax7_stable | GEO | Mus musculus | GSE87180 | 22,343 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |