STAT4
Information STAT4
- Description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
- Full Name
signal transducer and activator of transcription 4
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 7
- Biotypes
- 3
- Peaks
- 77,228
- Non-redundant peaks
- 53,576
TF Classification
- Familly
- STAT domain factors
- Sub Familly
- STAT factors
Source JASPAR
External IDs
- NCBI Gene
- 20849
- Official Gene Name
- Stat4
- JASPAR
- MA0518.1
- MGI
- MGI:103062
- Ensembl
- ENSMUSG00000062939
- UniProt
- Genevisible
- RefSeq
- NM_011487
- Aliases
Datasets Table for STAT4
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| STAT4 | spleen | IL12-IL18_KO | GEO | Mus musculus | GSE106137 | 3,499 | ||
| STAT4 | spleen | GEO | Mus musculus | GSE106137 | 111 | |||
| STAT4 | Th1 | GEO | Mus musculus | GSE22104 | 40,672 | |||
| STAT4 | Th1 | KO | GEO | Mus musculus | GSE22104 | 6,981 | ||
| STAT4 | Th2 | GEO | Mus musculus | GSE22104 | 13,965 | |||
| STAT4 | Th2 | KO | GEO | Mus musculus | GSE22104 | 1,217 | ||
| STAT4 | spleen | IL12-IL18 | GEO | Mus musculus | GSE106137 | 10,783 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |