T

Information T

Description

The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Variation in this gene was associated with susceptibility to neural tube defects and chordoma. A mutation in this gene was found in a family with sacral agenesis with vertebral anomalies. [provided by RefSeq, Sep 2018]

Full Name

T-box transcription factor T

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
2
Biotypes
1
Peaks
57,059
Non-redundant peaks
50,485

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
6862
Official Gene Name
TBXT
JASPAR
MA0009
Ensembl
ENSG00000164458
UniProt
O15178
Genevisible
O15178
RefSeq
NM_001270484
Aliases
SAVA; T; TFT
All peaks T
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Non redundant peaks T
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Datasets Table for T

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
T H9 ENDODERM GEO Homo sapiens GSE60606 23,419
T H9 MESODERM GEO Homo sapiens GSE60606 33,640
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks