TBP

Information TBP

Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]

Full Name

TATA-box binding protein

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
20
Biotypes
9
Peaks
350,702
Non-redundant peaks
136,028

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
6908
Official Gene Name
TBP
JASPAR
Ensembl
ENSG00000112592
UniProt
P20226
Genevisible
P20226
RefSeq
NM_001172085
Aliases
GTF2D; GTF2D1; HDL4; SCA17; TFIID
All peaks TBP
Download BED file
Non redundant peaks TBP
Download BED file
SEQUENCES TBP
Download FASTA file
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Datasets Table for TBP

Target nameTarget modificationEcotype/StrainBiotypeBiotype modificationSourceSpeciesExperimentPeaks
TBP ME-1 GEO Homo sapiens GSE46044 15,028
TBP K-562 GEO Homo sapiens GSE55306 35,883
TBP WA01 ENCODE Homo sapiens ENCSR000ECB 31,400
TBP K-562 ENCODE Homo sapiens ENCSR000EHA 27,375
TBP Hep-G2 ENCODE Homo sapiens ENCSR000EEL 27,526
TBP GM12878 ENCODE Homo sapiens ENCSR000DZZ 7,209
TBP hESC 2h GEO Homo sapiens GSE122298 29,898
TBP hESC 10h GEO Homo sapiens GSE122298 25,129
TBP hESC GEO Homo sapiens GSE122298 30,525
TBP hESC 8h GEO Homo sapiens GSE122298 21,241
Target nameTarget modificationEcotype/StrainBiotypeBiotype modificationSourceSpeciesExperimentPeaks
Showing 1 to 10 of 20 entries