TBX21

Information TBX21

Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

Full Name

T-box transcription factor 21

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
3
Biotypes
3
Peaks
141,974
Non-redundant peaks
107,371

TF Classification

Super Class
Immunoglobulin fold
Class
T-Box factors
Familly
TBrain-related factors
Sub Familly
None

Source TFClass

External IDs

NCBI Gene
30009
Official Gene Name
TBX21
JASPAR
MA0690
Ensembl
ENSG00000073861
UniProt
Q9UL17
Genevisible
Q9UL17
RefSeq
NM_013351
Aliases
T-PET; T-bet; TBET; TBLYM
All peaks TBX21
Download BED file
Non redundant peaks TBX21
Download BED file
SEQUENCES TBX21
Download FASTA file
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Datasets Table for TBX21

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TBX21 GM12878 ENCODE Homo sapiens ENCSR739IHN 65,680
TBX21 CD4 Th1 GEO Homo sapiens GSE62482 21,383
TBX21 Th1 CD3-CD28_donor2 GEO Homo sapiens GSE81881 54,911
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks