TCF3

Information TCF3

Description

Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (PubMed:15226298, PubMed:18214987). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (PubMed:18214987). Together with TCF15, required for the mesenchymal to epithelial transition (PubMed:11309385, PubMed:15226298). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (PubMed:15226298, PubMed:18214987). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (PubMed:2181401). {ECO:0000250|UniProtKB:P15923, ECO:0000269|PubMed:11309385, ECO:0000269|PubMed:15226298, ECO:0000269|PubMed:18214987, ECO:0000269|PubMed:2181401}.(Source UnitProtKB).

Full Name

transcription factor 3

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
25
Biotypes
13
Peaks
599,741
Non-redundant peaks
244,913

TF Classification

Familly
Basic helix-loop-helix factors (bHLH)
Sub Familly
E2A-related factors

Source JASPAR

External IDs

NCBI Gene
21423
Official Gene Name
Tcf3
JASPAR
MA0522.1
MGI
MGI:98510
Ensembl
ENSMUSG00000020167
UniProt
P15806
Genevisible
P15806
RefSeq
NM_011548
Aliases
A1; AA408400; ALF2; AW209082; E12; E12/E47; E2A; E47; KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR; bHLHb21

External links
All peaks TCF3
Download BED file
Non redundant peaks TCF3
Download BED file
SEQUENCES TCF3
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for TCF3

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TCF3 myocyte ENCODE Mus musculus ENCSR000AIP 1,834
TCF3 thymocyte GEO Mus musculus GSE84974 9,402
TCF3 pre-B-cell IKDN GEO Mus musculus GSE86897 11,749
TCF3 pre-B-cell WT GEO Mus musculus GSE86897 22,243
TCF3 pre-pro-B-cell 6h GEO Mus musculus GSE21978 16,369
TCF3 plasmablast DSG GEO Mus musculus GSE77744 28,956
TCF3 thymus NKT GEO Mus musculus GSE89847 1,642
TCF3 B-cell HCHO GEO Mus musculus GSE77744 7,589
TCF3 B-cell HCHO_anti-CD40 GEO Mus musculus GSE77744 8,248
TCF3 B-cell DSG_anti-CD40 GEO Mus musculus GSE77744 30,266
TCF3 mESC GEO Mus musculus GSE70486 77,031
TCF3 EBs GEO Mus musculus GSE70486 63,265
TCF3 HFSC GEO Mus musculus GSE48878 37,854
TCF3 NSC E47-KO GEO Mus musculus GSE88991 38,558
TCF3 NSC GEO Mus musculus GSE88991 34,950
TCF3 NSC E12-KO GEO Mus musculus GSE88991 45,028
TCF3 T-cell DP GEO Mus musculus GSE21978 12,748
TCF3 plasmablast HCHO GEO Mus musculus GSE77744 10,929
TCF3 thymus DP GEO Mus musculus GSE89847 17,848
TCF3 liver GEO Mus musculus GSE111526 12,818
TCF3 B-cell HCHO_4d GEO Mus musculus GSE77744 6,830
TCF3 B-cell DSG GEO Mus musculus GSE77744 39,148
TCF3 B-cell DSG_4d GEO Mus musculus GSE77744 33,676
TCF3 B-cell DSG_FO GEO Mus musculus GSE77744 21,744
TCF3 B-cell HCHO_FO GEO Mus musculus GSE77744 9,016
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks