TCF7L2
Information TCF7L2
- Description
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000250, ECO:0000269|PubMed:21856776, ECO:0000269|PubMed:9697701}.(Source UnitProtKB).
- Full Name
transcription factor 7 like 2, T cell specific, HMG box
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 2
- Peaks
- 11,535
- Non-redundant peaks
- 11,363
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 21416
- Official Gene Name
- Tcf7l2
- JASPAR
- MGI
- MGI:1202879
- Ensembl
- ENSMUSG00000024985
- UniProt
- Q924A0
- Genevisible
- Q924A0
- RefSeq
- NM_009333
- Aliases
- TCF4B; TCF4E; Tcf-4; Tcf4; mTcf-4B; mTcf-4E
Datasets Table for TCF7L2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| TCF7L2 | cardiac-ventricle | Wntup | GEO | Mus musculus | GSE97761 | 695 | ||
| TCF7L2 | preadipocyte | GEO | Mus musculus | GSE129403 | 10,840 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |