TCF7L2

Information TCF7L2

Description

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000250, ECO:0000269|PubMed:21856776, ECO:0000269|PubMed:9697701}.(Source UnitProtKB).

Full Name

transcription factor 7 like 2, T cell specific, HMG box

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
2
Biotypes
2
Peaks
11,535
Non-redundant peaks
11,363

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
21416
Official Gene Name
Tcf7l2
JASPAR
MGI
MGI:1202879
Ensembl
ENSMUSG00000024985
UniProt
Q924A0
Genevisible
Q924A0
RefSeq
NM_009333
Aliases
TCF4B; TCF4E; Tcf-4; Tcf4; mTcf-4B; mTcf-4E
All peaks TCF7L2
Download BED file
Non redundant peaks TCF7L2
Download BED file
SEQUENCES TCF7L2
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for TCF7L2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TCF7L2 cardiac-ventricle Wntup GEO Mus musculus GSE97761 695
TCF7L2 preadipocyte GEO Mus musculus GSE129403 10,840
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks