TCF7L2

Information TCF7L2

Description

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Full Name

transcription factor 7 like 2

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
18
Biotypes
11
Peaks
249,332
Non-redundant peaks
132,076

TF Classification

Super Class
Other all-alpha-helical DNA-binding domains
Class
High-mobility group (HMG) domain factors
Familly
TCF-7-related factors
Sub Familly
None

Source TFClass

External IDs

NCBI Gene
6934
Official Gene Name
TCF7L2
JASPAR
MA0830
Ensembl
ENSG00000148737
UniProt
Q9NQB0
Genevisible
Q9NQB0
RefSeq
NM_001146274
Aliases
TCF-4; TCF4
All peaks TCF7L2
Download BED file
Non redundant peaks TCF7L2
Download BED file
SEQUENCES TCF7L2
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for TCF7L2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TCF7L2 CD34 PROG_BIO GEO Homo sapiens GSE29194 12,541
TCF7L2 Hep-G2 ENCODE Homo sapiens ENCSR346BOD 28,183
TCF7L2 LNCaP GEO Homo sapiens GSE51621 27,865
TCF7L2 PANC-1 ENCODE Homo sapiens ENCSR000EXL 25,879
TCF7L2 MCF-7 ENCODE Homo sapiens ENCSR000EWT 9,286
TCF7L2 K-562 ENCODE Homo sapiens ENCSR888XZK 4,491
TCF7L2 Hep-G2 ENCODE Homo sapiens ENCSR000EVQ 2,120
TCF7L2 HEK293 ENCODE Homo sapiens ENCSR000EUY 9,544
TCF7L2 MDA-MB-453 DHT GEO Homo sapiens GSE45201 342
TCF7L2 MDA-MB-453 GEO Homo sapiens GSE45201 19,569
TCF7L2 HeLa-S3 ENCODE Homo sapiens ENCSR000EVE 20,372
TCF7L2 HeLa-S3 ENCODE Homo sapiens ENCSR000EVF 2,950
TCF7L2 HCT-116 ENCODE Homo sapiens ENCSR000EUV 51,248
TCF7L2 HCT-116 C16 GEO Homo sapiens GSE127960 6,758
TCF7L2 HCT-116 sc2 GEO Homo sapiens GSE127960 10,265
TCF7L2 HCT-116 WT GEO Homo sapiens GSE127960 5,660
TCF7L2 HCT-116 C18 GEO Homo sapiens GSE127960 6,120
TCF7L2 hepatocellular-carcinoma-cell 420 GEO Homo sapiens GSE138781 6,139
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks