TERF2

Information TERF2

Description

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length. {ECO:0000269|PubMed:20339076, ECO:0000269|PubMed:20619712, ECO:0000269|PubMed:20622870}.(Source UnitProtKB).

Full Name

telomeric repeat binding factor 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
2
Biotypes
1
Peaks
33,731
Non-redundant peaks
28,498

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
21750
Official Gene Name
Terf2
JASPAR
MGI
MGI:1195972
Ensembl
ENSMUSG00000031921
UniProt
O35144
Genevisible
O35144
RefSeq
Aliases
TRF2
All peaks TERF2
Download BED file
Non redundant peaks TERF2
Download BED file
SEQUENCES TERF2
Download FASTA file
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Datasets Table for TERF2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TERF2 testis GEO Mus musculus GSE79601 24,377
TERF2 testis KO GEO Mus musculus GSE79601 9,354
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks