TERF2IP

Information TERF2IP

Description

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:20339076, ECO:0000269|PubMed:20622869, ECO:0000269|PubMed:20622870}.(Source UnitProtKB).

Full Name

telomeric repeat binding factor 2, interacting protein

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
3
Biotypes
1
Peaks
467
Non-redundant peaks
230

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
57321
Official Gene Name
Terf2ip
JASPAR
MGI
MGI:1929871
Ensembl
ENSMUSG00000033430
UniProt
Q91VL8
Genevisible
Q91VL8
RefSeq
Aliases
Rap1
All peaks TERF2IP
Download BED file
Non redundant peaks TERF2IP
Download BED file
SEQUENCES TERF2IP
Download FASTA file
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Datasets Table for TERF2IP

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TERF2IP MEF KO_G3 GEO Mus musculus GSE79996 157
TERF2IP MEF KO_G1 GEO Mus musculus GSE79996 159
TERF2IP MEF KO GEO Mus musculus GSE79996 151
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks