TERT

Information TERT

Description

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

Full Name

telomerase reverse transcriptase

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
4
Biotypes
4
Peaks
1,055
Non-redundant peaks
384

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
7015
Official Gene Name
TERT
JASPAR
Ensembl
ENSG00000164362
UniProt
O14746
Genevisible
O14746
RefSeq
Aliases
CMM9; DKCA2; DKCB4; EST2; PFBMFT1; TCS1; TP2; TRT; hEST2; hTRT
All peaks TERT
Download BED file
Non redundant peaks TERT
Download BED file
SEQUENCES TERT
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for TERT

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TERT LOX-IMVI GEO Homo sapiens GSE77146 215
TERT BLM GEO Homo sapiens GSE77146 255
TERT P493-6 GEO Homo sapiens GSE77146 357
TERT hESC-1 GEO Homo sapiens GSE77146 228
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks