TET2

Information TET2

Description

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:20639862, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23352454, ECO:0000269|PubMed:23353889}.(Source UnitProtKB).

Full Name

tet methylcytosine dioxygenase 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
14
Biotypes
6
Peaks
341,866
Non-redundant peaks
182,973

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
214133
Official Gene Name
Tet2
JASPAR
MGI
MGI:2443298
Ensembl
ENSMUSG00000040943
UniProt
Q4JK59
Genevisible
Q4JK59
RefSeq
NM_001346736
Aliases
Ayu17-449; E130014J05Rik
All peaks TET2
Download BED file
Non redundant peaks TET2
Download BED file
SEQUENCES TET2
Download FASTA file
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Datasets Table for TET2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TET2 spleen GEO Mus musculus GSE116207 677
TET2 hematopoietic-cell Tet2-KO GEO Mus musculus GSE115965 33,214
TET2 mESC GEO Mus musculus GSE115964 60,262
TET2 mESC SALL4-het GEO Mus musculus GSE57700 11,561
TET2 mESC parental GEO Mus musculus GSE115964 54,181
TET2 mESC GEO Mus musculus GSE57700 4,242
TET2 mESC GEO Mus musculus GSE41720 2,298
TET2 embryonic-carcinoma RA-48h GEO Mus musculus GSE82314 178
TET2 bone-marrow GEO Mus musculus GSE36620 36,865
TET2 hematopoietic-cell GEO Mus musculus GSE115965 50,821
TET2 AML Tet2-KO GEO Mus musculus GSE115965 24,204
TET2 AML GEO Mus musculus GSE115965 40,680
TET2 mESC SALL4-KO GEO Mus musculus GSE57700 9,002
TET2 mESC Tet2-KO GEO Mus musculus GSE115964 19,149
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks