TFCP2L1
Information TFCP2L1
- Description
Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:23942233, PubMed:26321140). With Klf2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/Stat3 and Wnt/beta-catenin signaling (PubMed:23942238, PubMed:23942233, PubMed:26321140). Required for normal duct development in the salivary gland and kidney (PubMed:17079272). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (PubMed:28577314). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, Oxgr1, Ca12, Slc4a1, Aqp6 and IC-specific transcription factor Foxi1 (PubMed:28577314). Regulates also the expression of Jag1 and subsequent notch signaling in the collecting duct (PubMed:28577314). Jag1 initiates notch signaling in PCs but inhibits notch signaling in ICs (PubMed:28577314). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (PubMed:11073954). Modulates the placental expression of CYP11A1 (By similarity). {ECO:0000250|UniProtKB:Q9NZI6, ECO:0000269|PubMed:11073954, ECO:0000269|PubMed:17079272, ECO:0000269|PubMed:23942233, ECO:0000269|PubMed:23942238, ECO:0000269|PubMed:26321140, ECO:0000269|PubMed:28577314}.(Source UnitProtKB).
- Full Name
transcription factor CP2-like 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 894
- Non-redundant peaks
- 894
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 81879
- Official Gene Name
- Tfcp2l1
- JASPAR
- MGI
- MGI:2444691
- Ensembl
- ENSMUSG00000026380
- UniProt
- Q3UNW5
- Genevisible
- Q3UNW5
- RefSeq
- NM_023755
- Aliases
- 1810030F05Rik; 4932442M07Rik; Cp2l1; Crtr-1; D930018N21Rik; LBP-9; Tcfcp2l1