THAP1
Information THAP1
- Description
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity). {ECO:0000250}.(Source UnitProtKB).
- Full Name
THAP domain containing, apoptosis associated protein 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 6,699
- Non-redundant peaks
- 6,699
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 73754
- Official Gene Name
- Thap1
- JASPAR
- MGI
- MGI:1921004
- Ensembl
- ENSMUSG00000037214
- UniProt
- Q8CHW1
- Genevisible
- Q8CHW1
- RefSeq
- Aliases
- 4833431A01Rik