TOP2A
Information TOP2A
- Description
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:1331984). May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (PubMed:24321095). {ECO:0000269|PubMed:1331984, ECO:0000269|PubMed:24321095}.(Source UnitProtKB).
- Full Name
topoisomerase (DNA) II alpha
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 6
- Biotypes
- 4
- Peaks
- 158,349
- Non-redundant peaks
- 109,815
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
Datasets Table for TOP2A
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| TOP2A | MEF | GEO | Mus musculus | GSE99195 | 48,390 | |||
| TOP2A | MEF | Top2b-KO | GEO | Mus musculus | GSE99195 | 57,681 | ||
| TOP2A | thymus | AIRE-KO | GEO | Mus musculus | GSE92597 | 699 | ||
| TOP2A | primary-B-cell | activated_24h | GEO | Mus musculus | GSE99195 | 22,917 | ||
| TOP2A | primary-B-cell | activated_12h | GEO | Mus musculus | GSE99195 | 11,888 | ||
| TOP2A | mESC | GEO | Mus musculus | GSE45625 | 16,774 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |