TOP2A

Information TOP2A

Description

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

Full Name

DNA topoisomerase II alpha

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
5
Biotypes
2
Peaks
9,283
Non-redundant peaks
9,243

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
7153
Official Gene Name
TOP2A
JASPAR
Ensembl
ENSG00000131747
UniProt
P11388
Genevisible
P11388
RefSeq
NM_001067
Aliases
TOP2; TP2A
All peaks TOP2A
Download BED file
Non redundant peaks TOP2A
Download BED file
SEQUENCES TOP2A
Download FASTA file
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Datasets Table for TOP2A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TOP2A K-562 Etoposide GEO Homo sapiens GSE79593 146
TOP2A K-562 pBQ GEO Homo sapiens GSE79593 828
TOP2A KG-1 etoposide GEO Homo sapiens GSE114048 5,347
TOP2A KG-1 no-mitoxantrone GEO Homo sapiens GSE114048 186
TOP2A KG-1 etoposide_VP16 GEO Homo sapiens GSE114048 2,776
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks