TP53

Information TP53

Description

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Full Name

tumor protein p53

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
126
Biotypes
32
Peaks
650,140
Non-redundant peaks
257,786

TF Classification

Super Class
Immunoglobulin fold
Class
p53 domain factors
Familly
p53-related factors
Sub Familly
None

Source TFClass

External IDs

NCBI Gene
7157
Official Gene Name
TP53
JASPAR
MA0106
Ensembl
ENSG00000141510
UniProt
P04637
Genevisible
P04637
RefSeq
NM_000546
Aliases
BCC7; BMFS5; LFS1; P53; TRP53
All peaks TP53
Download BED file
Non redundant peaks TP53
Download BED file
SEQUENCES TP53
Download FASTA file
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Datasets Table for TP53

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TP53 MCF-7 4h_IR_10Gy GEO Homo sapiens GSE100099 3,190
TP53 MCF-7 minus_Decitabine GEO Homo sapiens GSE100292 464
TP53 MCF-7 1h_IR_10Gy GEO Homo sapiens GSE100099 3,911
TP53 MCF-7 7-5h_IR_10Gy_Nutlin GEO Homo sapiens GSE100099 22,470
TP53 MCF-7 nutlin_2h GEO Homo sapiens GSE100292 1,289
TP53 MCF-7 2h_4GY GEO Homo sapiens GSE100292 248
TP53 MCF-7 plus_Decitabine GEO Homo sapiens GSE100292 519
TP53 MCF-7 2-5h_IR_10Gy GEO Homo sapiens GSE100099 5,978
TP53 A-549 2h_4GY GEO Homo sapiens GSE100292 2,277
TP53 SJSA-1 GEO Homo sapiens GSE86164 2,019
TP53 SJSA-1 nutlin GEO Homo sapiens GSE86164 10,194
TP53 lymphocyte 45_DXR GEO Homo sapiens GSE110368 2,947
TP53 lymphocyte 90 GEO Homo sapiens GSE110368 7,275
TP53 lymphocyte 104_Nutlin GEO Homo sapiens GSE110368 1,712
TP53 lymphocyte 116_Nutlin GEO Homo sapiens GSE110368 8,167
TP53 lymphocyte 116_DXR GEO Homo sapiens GSE110368 2,026
TP53 lymphocyte 45_Nutlin GEO Homo sapiens GSE110368 1,540
TP53 lymphocyte 90_Nutlin GEO Homo sapiens GSE110368 1,508
TP53 lymphocyte 45 GEO Homo sapiens GSE110368 528
TP53 lymphocyte 116 GEO Homo sapiens GSE110368 989
TP53 lymphocyte 90_DXR GEO Homo sapiens GSE110368 2,740
TP53 UACC-62 2h_4GY GEO Homo sapiens GSE100292 138
TP53 SaOS-2 GEO Homo sapiens GSE15780 28,563
TP53 SaOS-2 GEO Homo sapiens GSE51268 10,885
TP53 MOLM-13 R282W_DMSO GEO Homo sapiens GSE131484 7,309
TP53 MOLM-13 Y220C_DMSO GEO Homo sapiens GSE131484 298
TP53 MOLM-13 Y220C_Daunorubicin GEO Homo sapiens GSE131484 160
TP53 MOLM-13 M237I_DMSO GEO Homo sapiens GSE131484 128
TP53 MOLM-13 M237I_Daunorubicin GEO Homo sapiens GSE131484 194
TP53 MOLM-13 DMSO GEO Homo sapiens GSE131484 366
TP53 MOLM-13 R282W_Daunorubicin GEO Homo sapiens GSE131484 8,437
TP53 MOLM-13 Daunorubicin GEO Homo sapiens GSE131484 486
TP53 IMR-90 SENE GEO Homo sapiens GSE53491 5,423
TP53 IMR-90 NUT3A GEO Homo sapiens GSE58740 7,773
TP53 IMR-90 DMSO GEO Homo sapiens GSE58740 354
TP53 IMR-90 GEO Homo sapiens GSE31558 1,145
TP53 IMR-90 SENES_SHLUC GEO Homo sapiens GSE42728 19,659
TP53 IMR-90 GEO Homo sapiens GSE115940 4,579
TP53 IMR-90 GEO Homo sapiens GSE42728 9,865
TP53 IMR-90 SENES_SHP53 GEO Homo sapiens GSE42728 731
TP53 IMR-90 APO GEO Homo sapiens GSE53491 23,384
TP53 UACC-257 nutlin_2h GEO Homo sapiens GSE100292 537
TP53 UACC-257 2h_4GY GEO Homo sapiens GSE100292 1,895
TP53 MCF-7 GEO Homo sapiens GSE101737 163
TP53 BC-3 ENA Homo sapiens ERP014035 87
TP53 BC-3 NUT ENA Homo sapiens ERP014035 1,165
TP53 BC-3 TPA_24H ENA Homo sapiens ERP014035 146
TP53 A-498 2h_4GY GEO Homo sapiens GSE100292 1,824
TP53 MCF-10A Nutlin3A GEO Homo sapiens GSE111009 16,009
TP53 LOX-IMVI 2h_4GY GEO Homo sapiens GSE100292 941
TP53 Hep-G2 GEO Homo sapiens GSE64877 243
TP53 K-562 R282W_DMSO GEO Homo sapiens GSE131484 615
TP53 K-562 R248Q_Daunorubicin GEO Homo sapiens GSE131484 119
TP53 K-562 DMSO GEO Homo sapiens GSE131484 247
TP53 K-562 R282W_Daunorubicin GEO Homo sapiens GSE131484 3,061
TP53 K-562 Daunorubicin GEO Homo sapiens GSE131484 1,878
TP53 K-562 R175H_Daunorubicin GEO Homo sapiens GSE131484 129
TP53 K-562 R273H_Daunorubicin GEO Homo sapiens GSE131484 276
TP53 K-562 Y220C_Daunorubicin GEO Homo sapiens GSE131484 350
TP53 MDA-MB-231 GEO Homo sapiens GSE95303 67,224
TP53 SaOS-2 ENA Homo sapiens ERP002038 1,553
TP53 GM06170 GEO Homo sapiens GSE55727 18,193
TP53 keratinocyte CISP GEO Homo sapiens GSE56674 14,925
TP53 keratinocyte ADRIA GEO Homo sapiens GSE56674 7,887
TP53 keratinocyte GEO Homo sapiens GSE56674 4,636
TP53 MCF-7 NUT GEO Homo sapiens GSE47041 209
TP53 MCF-7 nutlin GEO Homo sapiens GSE86164 34,085
TP53 MCF-7 7-5h_IR_10Gy GEO Homo sapiens GSE100099 5,094
TP53 MCF-7 NCS-treated GEO Homo sapiens GSE101737 2,898
TP53 NCI-H460 2h_4GY GEO Homo sapiens GSE100292 1,189
TP53 H9 mesoderm GEO Homo sapiens GSE142050 4,795
TP53 H9 ectoderm_IFI16 GEO Homo sapiens GSE142050 1,716
TP53 H9 mesoderm_IFI16 GEO Homo sapiens GSE142050 1,004
TP53 H9 GEO Homo sapiens GSE142050 6,098
TP53 H9 ectoderm GEO Homo sapiens GSE142050 12,428
TP53 H9 IFI16 GEO Homo sapiens GSE142050 1,502
TP53 H9 GEO Homo sapiens GSE39912 2,839
TP53 U2OS DMSO GEO Homo sapiens GSE46641 3,229
TP53 U2OS GEO Homo sapiens GSE46641 607
TP53 PS15 U2OS ACTD GEO Homo sapiens GSE21939 521
TP53 U2OS UV_8H ENA Homo sapiens ERP004176 2,191
TP53 PS46 U2OS ACTD GEO Homo sapiens GSE21939 82
TP53 U2OS 10Gy_4h_recovery GEO Homo sapiens GSE110800 227
TP53 U2OS ENA Homo sapiens ERP004176 1,023
TP53 U2OS DXR GEO Homo sapiens GSE46641 2,397
TP53 U2OS ACTD GEO Homo sapiens GSE21939 550
TP53 PS15 U2OS ETO GEO Homo sapiens GSE21939 597
TP53 U2OS 2h_4GY GEO Homo sapiens GSE100292 253
TP53 U2OS UV_16H ENA Homo sapiens ERP004176 2,060
TP53 U2OS ETO GEO Homo sapiens GSE21939 1,102
TP53 U2OS 10Gy_2h_recovery GEO Homo sapiens GSE110800 168
TP53 PS46 U2OS ETO GEO Homo sapiens GSE21939 124
TP53 U2OS NUT GEO Homo sapiens GSE46641 16,948
TP53 Calu-1 WT-COMB GEO Homo sapiens GSE128673 894
TP53 Calu-1 WT-DMSO GEO Homo sapiens GSE128673 266
TP53 Calu-1 MUT8-COMB GEO Homo sapiens GSE128673 8,889
TP53 Calu-1 MUT8-DMSO GEO Homo sapiens GSE128673 963
TP53 SK-MEL-5 2h_4GY GEO Homo sapiens GSE100292 104
TP53 GM00011 GEO Homo sapiens GSE55727 11,485
TP53 hESC DIFF GEO Homo sapiens GSE39912 15,052
TP53 hESC DAMAGED GEO Homo sapiens GSE39912 19,584
TP53 SW480 0h_TNFa GEO Homo sapiens GSE102796 48,435
TP53 SW480 shp53_16h_TNF-a GEO Homo sapiens GSE115985 35,983
TP53 MALME-3 2h_4GY GEO Homo sapiens GSE100292 103
TP53 UO-31 2h_4GY GEO Homo sapiens GSE100292 3,457
TP53 NCI-H1299 ENA Homo sapiens ERP022459 269
TP53 HCT-116 2h_4GY GEO Homo sapiens GSE100292 1,095
TP53 HCT-116 DMSO_KOATF3 GEO Homo sapiens GSE74355 1,049
TP53 HCT-116 5FU GEO Homo sapiens GSE58506 3,382
TP53 HCT-116 nutlin GEO Homo sapiens GSE86164 5,941
TP53 HCT-116 CAMP GEO Homo sapiens GSE74355 82
TP53 HCT-116 IR GEO Homo sapiens GSE60267 7,301
TP53 HCT-116 GEO Homo sapiens GSE58714 63
TP53 HCT-116 GEO Homo sapiens GSE58506 665
TP53 HCT-116 Negative-ctrl GEO Homo sapiens GSE113338 1,027
TP53 HCT-116 Nutlin3a GEO Homo sapiens GSE125927 13,739
TP53 HCT-116 si-iASSP GEO Homo sapiens GSE113338 1,026
TP53 HCT-116 siGLIS2 GEO Homo sapiens GSE125927 313
TP53 HCT-116 Nutlin3a-SC GEO Homo sapiens GSE125927 1,752
TP53 HCT-116 5FU-SC GEO Homo sapiens GSE125927 661
TP53 HCT-116 siCtrl-5FU GEO Homo sapiens GSE125927 524
TP53 HCT-116 siGLIS2 GEO Homo sapiens GSE125927 2,332
TP53 HCT-116 5FU GEO Homo sapiens GSE125927 1,151
TP53 HCT-116 DMSO GEO Homo sapiens GSE125927 189
TP53 RPE 2h_4GY GEO Homo sapiens GSE100292 343
TP53 foreskin DMSO GEO Homo sapiens GSE111009 114
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks