TP53
Information TP53
- Description
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
- Full Name
tumor protein p53
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 126
- Biotypes
- 32
- Peaks
- 650,140
- Non-redundant peaks
- 257,786
TF Classification
- Super Class
- Immunoglobulin fold
- Class
- p53 domain factors
- Familly
- p53-related factors
- Sub Familly
- None
Source TFClass
Datasets Table for TP53
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
TP53 | MCF-7 | 4h_IR_10Gy | GEO | Homo sapiens | GSE100099 | 3,190 | ||
TP53 | MCF-7 | minus_Decitabine | GEO | Homo sapiens | GSE100292 | 464 | ||
TP53 | MCF-7 | 1h_IR_10Gy | GEO | Homo sapiens | GSE100099 | 3,911 | ||
TP53 | MCF-7 | 7-5h_IR_10Gy_Nutlin | GEO | Homo sapiens | GSE100099 | 22,470 | ||
TP53 | MCF-7 | nutlin_2h | GEO | Homo sapiens | GSE100292 | 1,289 | ||
TP53 | MCF-7 | 2h_4GY | GEO | Homo sapiens | GSE100292 | 248 | ||
TP53 | MCF-7 | plus_Decitabine | GEO | Homo sapiens | GSE100292 | 519 | ||
TP53 | MCF-7 | 2-5h_IR_10Gy | GEO | Homo sapiens | GSE100099 | 5,978 | ||
TP53 | A-549 | 2h_4GY | GEO | Homo sapiens | GSE100292 | 2,277 | ||
TP53 | SJSA-1 | GEO | Homo sapiens | GSE86164 | 2,019 | |||
TP53 | SJSA-1 | nutlin | GEO | Homo sapiens | GSE86164 | 10,194 | ||
TP53 | lymphocyte | 45_DXR | GEO | Homo sapiens | GSE110368 | 2,947 | ||
TP53 | lymphocyte | 90 | GEO | Homo sapiens | GSE110368 | 7,275 | ||
TP53 | lymphocyte | 104_Nutlin | GEO | Homo sapiens | GSE110368 | 1,712 | ||
TP53 | lymphocyte | 116_Nutlin | GEO | Homo sapiens | GSE110368 | 8,167 | ||
TP53 | lymphocyte | 116_DXR | GEO | Homo sapiens | GSE110368 | 2,026 | ||
TP53 | lymphocyte | 45_Nutlin | GEO | Homo sapiens | GSE110368 | 1,540 | ||
TP53 | lymphocyte | 90_Nutlin | GEO | Homo sapiens | GSE110368 | 1,508 | ||
TP53 | lymphocyte | 45 | GEO | Homo sapiens | GSE110368 | 528 | ||
TP53 | lymphocyte | 116 | GEO | Homo sapiens | GSE110368 | 989 | ||
TP53 | lymphocyte | 90_DXR | GEO | Homo sapiens | GSE110368 | 2,740 | ||
TP53 | UACC-62 | 2h_4GY | GEO | Homo sapiens | GSE100292 | 138 | ||
TP53 | SaOS-2 | GEO | Homo sapiens | GSE15780 | 28,563 | |||
TP53 | SaOS-2 | GEO | Homo sapiens | GSE51268 | 10,885 | |||
TP53 | MOLM-13 | R282W_DMSO | GEO | Homo sapiens | GSE131484 | 7,309 | ||
TP53 | MOLM-13 | Y220C_DMSO | GEO | Homo sapiens | GSE131484 | 298 | ||
TP53 | MOLM-13 | Y220C_Daunorubicin | GEO | Homo sapiens | GSE131484 | 160 | ||
TP53 | MOLM-13 | M237I_DMSO | GEO | Homo sapiens | GSE131484 | 128 | ||
TP53 | MOLM-13 | M237I_Daunorubicin | GEO | Homo sapiens | GSE131484 | 194 | ||
TP53 | MOLM-13 | DMSO | GEO | Homo sapiens | GSE131484 | 366 | ||
TP53 | MOLM-13 | R282W_Daunorubicin | GEO | Homo sapiens | GSE131484 | 8,437 | ||
TP53 | MOLM-13 | Daunorubicin | GEO | Homo sapiens | GSE131484 | 486 | ||
TP53 | IMR-90 | SENE | GEO | Homo sapiens | GSE53491 | 5,423 | ||
TP53 | IMR-90 | NUT3A | GEO | Homo sapiens | GSE58740 | 7,773 | ||
TP53 | IMR-90 | DMSO | GEO | Homo sapiens | GSE58740 | 354 | ||
TP53 | IMR-90 | GEO | Homo sapiens | GSE31558 | 1,145 | |||
TP53 | IMR-90 | SENES_SHLUC | GEO | Homo sapiens | GSE42728 | 19,659 | ||
TP53 | IMR-90 | GEO | Homo sapiens | GSE115940 | 4,579 | |||
TP53 | IMR-90 | GEO | Homo sapiens | GSE42728 | 9,865 | |||
TP53 | IMR-90 | SENES_SHP53 | GEO | Homo sapiens | GSE42728 | 731 | ||
TP53 | IMR-90 | APO | GEO | Homo sapiens | GSE53491 | 23,384 | ||
TP53 | UACC-257 | nutlin_2h | GEO | Homo sapiens | GSE100292 | 537 | ||
TP53 | UACC-257 | 2h_4GY | GEO | Homo sapiens | GSE100292 | 1,895 | ||
TP53 | MCF-7 | GEO | Homo sapiens | GSE101737 | 163 | |||
TP53 | BC-3 | ENA | Homo sapiens | ERP014035 | 87 | |||
TP53 | BC-3 | NUT | ENA | Homo sapiens | ERP014035 | 1,165 | ||
TP53 | BC-3 | TPA_24H | ENA | Homo sapiens | ERP014035 | 146 | ||
TP53 | A-498 | 2h_4GY | GEO | Homo sapiens | GSE100292 | 1,824 | ||
TP53 | MCF-10A | Nutlin3A | GEO | Homo sapiens | GSE111009 | 16,009 | ||
TP53 | LOX-IMVI | 2h_4GY | GEO | Homo sapiens | GSE100292 | 941 | ||
TP53 | Hep-G2 | GEO | Homo sapiens | GSE64877 | 243 | |||
TP53 | K-562 | R282W_DMSO | GEO | Homo sapiens | GSE131484 | 615 | ||
TP53 | K-562 | R248Q_Daunorubicin | GEO | Homo sapiens | GSE131484 | 119 | ||
TP53 | K-562 | DMSO | GEO | Homo sapiens | GSE131484 | 247 | ||
TP53 | K-562 | R282W_Daunorubicin | GEO | Homo sapiens | GSE131484 | 3,061 | ||
TP53 | K-562 | Daunorubicin | GEO | Homo sapiens | GSE131484 | 1,878 | ||
TP53 | K-562 | R175H_Daunorubicin | GEO | Homo sapiens | GSE131484 | 129 | ||
TP53 | K-562 | R273H_Daunorubicin | GEO | Homo sapiens | GSE131484 | 276 | ||
TP53 | K-562 | Y220C_Daunorubicin | GEO | Homo sapiens | GSE131484 | 350 | ||
TP53 | MDA-MB-231 | GEO | Homo sapiens | GSE95303 | 67,224 | |||
TP53 | SaOS-2 | ENA | Homo sapiens | ERP002038 | 1,553 | |||
TP53 | GM06170 | GEO | Homo sapiens | GSE55727 | 18,193 | |||
TP53 | keratinocyte | CISP | GEO | Homo sapiens | GSE56674 | 14,925 | ||
TP53 | keratinocyte | ADRIA | GEO | Homo sapiens | GSE56674 | 7,887 | ||
TP53 | keratinocyte | GEO | Homo sapiens | GSE56674 | 4,636 | |||
TP53 | MCF-7 | NUT | GEO | Homo sapiens | GSE47041 | 209 | ||
TP53 | MCF-7 | nutlin | GEO | Homo sapiens | GSE86164 | 34,085 | ||
TP53 | MCF-7 | 7-5h_IR_10Gy | GEO | Homo sapiens | GSE100099 | 5,094 | ||
TP53 | MCF-7 | NCS-treated | GEO | Homo sapiens | GSE101737 | 2,898 | ||
TP53 | NCI-H460 | 2h_4GY | GEO | Homo sapiens | GSE100292 | 1,189 | ||
TP53 | H9 | mesoderm | GEO | Homo sapiens | GSE142050 | 4,795 | ||
TP53 | H9 | ectoderm_IFI16 | GEO | Homo sapiens | GSE142050 | 1,716 | ||
TP53 | H9 | mesoderm_IFI16 | GEO | Homo sapiens | GSE142050 | 1,004 | ||
TP53 | H9 | GEO | Homo sapiens | GSE142050 | 6,098 | |||
TP53 | H9 | ectoderm | GEO | Homo sapiens | GSE142050 | 12,428 | ||
TP53 | H9 | IFI16 | GEO | Homo sapiens | GSE142050 | 1,502 | ||
TP53 | H9 | GEO | Homo sapiens | GSE39912 | 2,839 | |||
TP53 | U2OS | DMSO | GEO | Homo sapiens | GSE46641 | 3,229 | ||
TP53 | U2OS | GEO | Homo sapiens | GSE46641 | 607 | |||
TP53 | PS15 | U2OS | ACTD | GEO | Homo sapiens | GSE21939 | 521 | |
TP53 | U2OS | UV_8H | ENA | Homo sapiens | ERP004176 | 2,191 | ||
TP53 | PS46 | U2OS | ACTD | GEO | Homo sapiens | GSE21939 | 82 | |
TP53 | U2OS | 10Gy_4h_recovery | GEO | Homo sapiens | GSE110800 | 227 | ||
TP53 | U2OS | ENA | Homo sapiens | ERP004176 | 1,023 | |||
TP53 | U2OS | DXR | GEO | Homo sapiens | GSE46641 | 2,397 | ||
TP53 | U2OS | ACTD | GEO | Homo sapiens | GSE21939 | 550 | ||
TP53 | PS15 | U2OS | ETO | GEO | Homo sapiens | GSE21939 | 597 | |
TP53 | U2OS | 2h_4GY | GEO | Homo sapiens | GSE100292 | 253 | ||
TP53 | U2OS | UV_16H | ENA | Homo sapiens | ERP004176 | 2,060 | ||
TP53 | U2OS | ETO | GEO | Homo sapiens | GSE21939 | 1,102 | ||
TP53 | U2OS | 10Gy_2h_recovery | GEO | Homo sapiens | GSE110800 | 168 | ||
TP53 | PS46 | U2OS | ETO | GEO | Homo sapiens | GSE21939 | 124 | |
TP53 | U2OS | NUT | GEO | Homo sapiens | GSE46641 | 16,948 | ||
TP53 | Calu-1 | WT-COMB | GEO | Homo sapiens | GSE128673 | 894 | ||
TP53 | Calu-1 | WT-DMSO | GEO | Homo sapiens | GSE128673 | 266 | ||
TP53 | Calu-1 | MUT8-COMB | GEO | Homo sapiens | GSE128673 | 8,889 | ||
TP53 | Calu-1 | MUT8-DMSO | GEO | Homo sapiens | GSE128673 | 963 | ||
TP53 | SK-MEL-5 | 2h_4GY | GEO | Homo sapiens | GSE100292 | 104 | ||
TP53 | GM00011 | GEO | Homo sapiens | GSE55727 | 11,485 | |||
TP53 | hESC | DIFF | GEO | Homo sapiens | GSE39912 | 15,052 | ||
TP53 | hESC | DAMAGED | GEO | Homo sapiens | GSE39912 | 19,584 | ||
TP53 | SW480 | 0h_TNFa | GEO | Homo sapiens | GSE102796 | 48,435 | ||
TP53 | SW480 | shp53_16h_TNF-a | GEO | Homo sapiens | GSE115985 | 35,983 | ||
TP53 | MALME-3 | 2h_4GY | GEO | Homo sapiens | GSE100292 | 103 | ||
TP53 | UO-31 | 2h_4GY | GEO | Homo sapiens | GSE100292 | 3,457 | ||
TP53 | NCI-H1299 | ENA | Homo sapiens | ERP022459 | 269 | |||
TP53 | HCT-116 | 2h_4GY | GEO | Homo sapiens | GSE100292 | 1,095 | ||
TP53 | HCT-116 | DMSO_KOATF3 | GEO | Homo sapiens | GSE74355 | 1,049 | ||
TP53 | HCT-116 | 5FU | GEO | Homo sapiens | GSE58506 | 3,382 | ||
TP53 | HCT-116 | nutlin | GEO | Homo sapiens | GSE86164 | 5,941 | ||
TP53 | HCT-116 | CAMP | GEO | Homo sapiens | GSE74355 | 82 | ||
TP53 | HCT-116 | IR | GEO | Homo sapiens | GSE60267 | 7,301 | ||
TP53 | HCT-116 | GEO | Homo sapiens | GSE58714 | 63 | |||
TP53 | HCT-116 | GEO | Homo sapiens | GSE58506 | 665 | |||
TP53 | HCT-116 | Negative-ctrl | GEO | Homo sapiens | GSE113338 | 1,027 | ||
TP53 | HCT-116 | Nutlin3a | GEO | Homo sapiens | GSE125927 | 13,739 | ||
TP53 | HCT-116 | si-iASSP | GEO | Homo sapiens | GSE113338 | 1,026 | ||
TP53 | HCT-116 | siGLIS2 | GEO | Homo sapiens | GSE125927 | 313 | ||
TP53 | HCT-116 | Nutlin3a-SC | GEO | Homo sapiens | GSE125927 | 1,752 | ||
TP53 | HCT-116 | 5FU-SC | GEO | Homo sapiens | GSE125927 | 661 | ||
TP53 | HCT-116 | siCtrl-5FU | GEO | Homo sapiens | GSE125927 | 524 | ||
TP53 | HCT-116 | siGLIS2 | GEO | Homo sapiens | GSE125927 | 2,332 | ||
TP53 | HCT-116 | 5FU | GEO | Homo sapiens | GSE125927 | 1,151 | ||
TP53 | HCT-116 | DMSO | GEO | Homo sapiens | GSE125927 | 189 | ||
TP53 | RPE | 2h_4GY | GEO | Homo sapiens | GSE100292 | 343 | ||
TP53 | foreskin | DMSO | GEO | Homo sapiens | GSE111009 | 114 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |